RESEARCH CENTER FOR CEREBRAL VASCULAR DISEASE

脑血管疾病研究中心

• 批准号: 3099241
• 负责人: MYRON DAVID GINSBERG
• 金额: $ 108.5万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099241
• 关键词: bioenergetics; brain circulation; brain injury; brain metabolism; cerebral ischemia /hypoxia

The objective of our research program is to conduct an integrated multidisciplinary inquiry into the mechanisms and treatment of ischemic brain injury. Our investigations, grounded in experimental animal models of cerebral ischemia, have as their ultimate goal the identification of those factors responsible for ischemic injury which may be amenable to therapeutic or prophylactic intervention. The Program Project consists of six investigative proposal together with Core facilities supporting the research program in the areas of brain metabolite analysis, animal physiology, radioisotopic tracer strategies, morphology, computer science/image-processing, and animal behavior. The Cores contribute substantively to the implementation of each Project and unify the Projects by common methodological approaches. Program areas include: (1) treatable mechanisms of brain injury in foal cerebral ischemia; (2) mechanisms of functional recovery following cerebral infarction; (3) an analysis of glutamatergic mediation of ischemic vulnerability; (4) the effect of mild selective cerebral hypothermia in protecting against ischemic brain injury; (5) studies of early indices of cellular damage in the hippocampal slice preparation; and (6) an analysis of local cortical electrophysiological and ion-transport alterations in acute focal cerebral ischemia and their relationship to ultimate tissue injury.

我们研究计划的目标是进行综合 缺血性脑病的机制和治疗的多学科探究 脑损伤。 我们的研究以实验动物模型为基础 脑缺血的最终目标是确定 那些可能导致缺血性损伤的因素 治疗或预防性干预。 该计划项目包括 六项调查建议以及核心设施支持 脑代谢物分析、动物领域的研究计划 生理学、放射性同位素示踪剂策略、形态学、计算机 科学/图像处理和动物行为。 核心贡献 切实落实各项目并统一 采用通用方法论的项目。 计划领域包括： (1)马驹脑缺血脑损伤的可治疗机制； (2) 脑梗塞后功能恢复的机制； (3) 一个 分析谷氨酸能介导缺血性脆弱性； (4) 的 选择性轻度脑低温治疗的预防作用 缺血性脑损伤； (5) 细胞损伤早期指标的研究 海马切片制备； (6)局部皮质分析 急性局灶性电生理和离子传输的改变 脑缺血及其与最终组织损伤的关系。