Defining the role of zinc in human macrophage responses to Salmonella

定义锌在人类巨噬细胞对沙门氏菌反应中的作用

• 批准号: nhmrc : 1065391
• 负责人: Prof Matthew Sweet
• 金额: $ 39.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-zinc-responses-salmonella/455164
• 关键词: Defining; role; zinc; human; macrophage

It is estimated that one third of the worlds population is affected by mild to moderate zinc deficiency, and that this predisposes to a range of infectious diseases. The immunomodulatory effects of zinc have been appreciated for many years, and indeed zinc supplementation is used to treat severe diarrhoeal diseases. This project aims to understand the anti-infective mechanisms of zinc by focusing on macrophages, a key cell type involved in killing invading microorganisms.

据估计，世界上三分之一的人口受到轻度至中度缺锌的影响，这容易导致一系列传染病。锌的免疫调节作用多年来一直受到人们的重视，事实上，补锌可用于治疗严重的腹泻疾病。该项目旨在通过关注巨噬细胞（一种参与杀死入侵微生物的关键细胞类型）来了解锌的抗感染机制。