Toll-like receptors and innate immunity: genes and pathways regulating infectious and inflammatory diseases

先天免疫系统是抵御传染病的第一道防线，但也有助于炎症性疾病的病理（如类风湿性关节炎）。我研究先天免疫系统使用的特定基因和途径，以(1)了解先天免疫系统如何预防感染以及微生物如何克服这些防御，以及(2)开发阻断炎症的方法。结果可能包括炎症和感染性疾病的新疗法。

The innate immune system is the first line of defence against infectious diseases, but also contributes to the pathology of inflammatory diseases (e.g. rheumatoid arthritis). I study specific genes and pathways used by the innate immune system to (1) understand how the innate immune system prevents infections and how microorganisms overcome these defences, and (2) develop approaches to block inflammation. Outcomes may include new therapies for inflammatory and infectious diseases.