Pattern Recognition Receptors in Inflammation and Infection

炎症和感染中的模式识别受体

• 批准号: nhmrc : GNT1107914
• 负责人: Prof Matthew Sweet
• 金额: $ 62.27万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pattern-recognition-receptors-inflammation-infection/1346610
• 关键词: Pattern; Recognition; Receptors; Inflammation; Infection

Innate immunity provides our first line of defence against infections, but pathogens can overcome this system. Understanding how microbes disable innate immunity can teach us how to prevent and/or treat infectious diseases. Innate immunity acts by initiating inflammation. Many important acute and chronic diseases develop when this process is dysregulated. Blocking innate immunity thus has potential to treat many diseases. This project aims to understand innate immunity in these contexts.

先天免疫力是我们对抗感染的第一道防线，但病原体可以克服这一系统。了解微生物如何破坏先天免疫可以教我们如何预防和/或治疗传染病。先天免疫通过引发炎症起作用。当这一过程失调时，许多重要的急性和慢性疾病就会发生。因此，阻断先天免疫有可能治疗许多疾病。该项目旨在了解这些背景下的先天免疫。