Mitochondria as sensors of environmental threats

该项目旨在了解产生能量的线粒体如何控制免疫反应，无论是在名为巨噬细胞的免疫细胞中，还是在线虫(一种自由生活的蛔虫，用作研究基因功能和进化生物学的模式生物)中。该项目希望推进有关线粒体裂变过程如何使细胞对环境威胁做出反应的知识。预期成果包括细胞生物学和遗传学方面的重要概念进展、新的国际和国家合作以及改进的细胞生物学研究方法。预期的好处包括一个可长期间接应用于制定防治感染的新战略的知识库。

This project aims to understand how energy-generating mitochondria control immune responses, both in immune cells called macrophages and in the nematode Caenorhabditis elegans (a free-living roundworm used as a model organism to study gene function and evolutionary biology). The project expects to advance knowledge of how a process called mitochondrial fission enables cells to respond to environmental threats. Expected outcomes include important conceptual advances in cell biology and genetics, new international and national collaborations, and improved methods for cell biology research. Anticipated benefits include a knowledge base that can be indirectly applied in the long term in the development of new strategies to combat infections.