Mitochondria as sensors of environmental threats

线粒体作为环境威胁的传感器

• 批准号: DP230102124
• 负责人: Prof Matthew Sweet
• 金额: $ 39.4万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102124
• 关键词: Mitochondria; sensors; environmental; threats

This project aims to understand how energy-generating mitochondria control immune responses, both in immune cells called macrophages and in the nematode Caenorhabditis elegans (a free-living roundworm used as a model organism to study gene function and evolutionary biology). The project expects to advance knowledge of how a process called mitochondrial fission enables cells to respond to environmental threats. Expected outcomes include important conceptual advances in cell biology and genetics, new international and national collaborations, and improved methods for cell biology research. Anticipated benefits include a knowledge base that can be indirectly applied in the long term in the development of new strategies to combat infections.

该项目旨在了解产生能量的线粒体如何控制免疫反应，无论是在称为巨噬细胞的免疫细胞中还是在线虫线虫中（一种自由生活的蛔虫，用作研究基因功能和进化生物学的模型生物）。该项目预计将进一步了解一种称为线粒体裂变的过程如何使细胞能够应对环境威胁。预期成果包括细胞生物学和遗传学的重要概念进展、新的国际和国家合作以及改进的细胞生物学研究方法。预期的好处包括建立一个知识库，可长期间接用于制定防治感染的新战略。