ANTIDEPRESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER AND NORMAL CONTROL

我们之前已经证明，眼睛暴露在强光下，但不是 普通房间光线可以逆转慢性阻塞性肺病患者的冬季抑郁症状 季节性情感障碍(SAD)。到目前为止，人们普遍认为 光疗是治疗SAD的有效方法。常规灯光 治疗方法是让病人坐在一个 大灯箱。虽然有效，但这些盒子要求患者 在治疗期间留在一个地方，很难 运输。为了避免这些问题，我们开发了一种头盔 轻型护目镜，轻便，便于携带，使患者 在接受治疗的同时移动。为了测试面罩的功效，我们 比较了两种不同的遮光罩的效果，其中一种更亮(7000勒克斯) 和一个调光器(400勒克斯)，在55名SAD患者的三个地点：贝塞斯达， 西雅图和纳舒亚。每天进行30-60分钟的治疗 一周的时间。与我们的预测相反，我们发现较暗的面罩是 比更亮的更有效，响应率为56%，而 27%。我们讨论了这种矛盾发现的可能原因，并概述了 需要后续研究来证实其有效性。

We have previously shown that exposure of the eyes to bright light but not ordinary room light can reverse winter depressive symptoms in patients with Seasonal Affective Disorder (SAD). By now it is generally accepted that light therapy is an effective treatment for SAD. Conventional light treatment has been administered by having the patient sit in front of a large light box. Although effective, these boxes require that the patient remain in one place for the duration of treatment and are difficult to transport. To obviate these problems, we have developed a head-mounted light visor, which is light, easily portable and allows the patient to be mobile while receiving treatment. To test the efficacy of the visor, we compared the effects of two different light visors, one brighter (7000 lux) and one dimmer (400 lux), in 55 SAD patients at three sites: Bethesda, Seattle and Nashua. Treatment was administered for 30-60 minutes per day for one week. Contrary to our prediction, we found the dimmer visor to be more effective than the brighter one, yielding a response rate of 56% vs. 27%. We discuss possible reasons for this paradoxical findings and outline follow-up studies needed to corroborate its validity.