EFFECTS OF LIGHT IN HIV PATIENTS

光对艾滋病毒患者的影响

• 批准号: 3859920
• 负责人: N E ROSENTHAL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859920
• 关键词: HIV infections; blood cell count; cellular immunity; helper T lymphocyte; human subject; light intensity; phototherapy; seasonal affective disorder; suppressor T lymphocyte

In previous years we found that patients with winter seasonal affective disorder (SAD) had certain in vitro immunological abnormalities, which were restored to normality following effective light therapy. Subsequently we showed that bright light treatment increased the number of circulating CD4 (helper)-T cells in direct proportion to its antidepressant effect in a sample of the general population. Since HIV virus, among its many pathogenic effects, results in decreased numbers of circulating CD4 cells, we hypothesized that bright light exposure might increase the number of these cells in the circulation of HIV-infected individuals. To test the above hypothesis, we recruited 35 HIV-infected individuals, 17 with a history of SAD and 18 without such a history. We treated these individuals in a crossover study, using two different light sources for 45 minutes each morning for a total of four weeks. We predicted that the bright (10,000 lux) white light source would have an elevating effect on the CD4 cells, as compared with the dim (175 lux) red light source. Analysis of variance showed a significant effect of treatment on CD8 cell counts and a trend towards such an effect for CD4 counts. When the post- treatment results were compared directly, there was a small but statistically significant elevation in both CD4 and CD8 counts following the bright white treatment as compared with the dim red control. There was no difference between the SAD and the non-SAD groups with regard to their response to light. In addition, there was no evidence that the effects of light on immune cell levels was mediated by its effects on mood. The small effect size raises questions as to whether light might be of any value as an adjunctive treatment in HIV infected individuals. Studies of longer duration will be needed before this question can be answered. On the basis of the present study it appears that light treatment can be administered safely to HIV-infected individuals who need it for reasons unrelated to their infection.

往年我们发现冬季季节性情感障碍患者 疾病（SAD）有一定的体外免疫异常， 经过有效的光疗后恢复正常。 而后 结果表明，强光处理增加了循环CD 4+细胞的数量， （辅助）-T细胞与其抗抑郁作用成正比， 一般人群的样本。 自从艾滋病毒，其中许多 致病作用，导致循环CD 4细胞数量减少， 我们假设强光照射可能会增加 这些细胞在HIV感染者的血液循环中。 为了验证上述假设，我们招募了35名艾滋病毒感染者，其中17名 有SAD病史和18名无SAD病史的患者 我们把这些 在交叉研究中，使用两种不同的光源， 每天早上10分钟，总共四周。 我们预测， 明亮（10，000勒克斯）的白色光源将对 CD 4细胞，与暗淡的（175勒克斯）红色光源相比。 方差分析显示，治疗对CD 8细胞的影响显著 计数和CD 4计数的这种影响趋势。 当邮报- 治疗结果直接比较，有一个小，但 CD 4和CD 8计数在以下治疗后均出现统计学显著性升高 明亮的白色处理与暗淡的红色对照相比。 有 SAD组和非SAD组之间在 对光的反应。 此外，没有证据表明， 光对免疫细胞水平的影响是通过其对情绪的影响来介导的。 小的效应大小提出了一个问题，即光是否可能是任何 作为HIV感染者的预防性治疗的价值。 研究 这问题需要较长的时间才能回答。 对 本研究的基础是，光处理似乎可以 安全地给予因某些原因需要它的HIV感染者 与感染无关。