EFFECTS OF LIGHT INTERVENTIONS IN SEASONAL AFFECTIVE DISORDER
EFFECTS OF LIGHT INTERVENTIONS IN SEASONAL AFFECTIVE DISORDER
批准号:
4696479
负责人:
N E ROSENTHAL
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
我们之前在四组独立的成年患者中
英文摘要
We have previously shown in four separate groups of adult patients with
seasonal affective disorder (SAD) that exposing these patients to bright
full-spectrum light for 3 hours in the morning and 3 hours in the evening,
or for 5 hours in the evening alone, produces marked antidepressant
effects. In this past year we examined whether the antidepressant effects
are mediated via the photoperiod, i.e., whether they depend on extending
the normal daylength or whether they will occur even if the light exposure
takes place within normal daylight hours. We treated 7 inpatients with SAD
in a crossover design involving two 1-week light manipulations separated by
a week off lights. The 2 lighting manipulations both involved 2 3-hour
periods of bright (2500 lux) light, separated either by 2 hours of dim
light (short skeleton photoperiod) or 9 hours of dim light (long skeleton
photoperiod). Based on animal studies we predicted that the latter would
have antidepressant effects in our patients but that the former would not.
In fact, we found the treatment schedules to be equally efficacious, which
would argue against a photoperiodic mechanism for the antidepressant
effects of bright environmental light in SAD.
We collaborated with Dr. Carla Hellekson in Fairbanks, Alaska, who showed
in 6 patients with SAD that two hours of bright light in the morning, two
hours of bright light in the evening, and two hours f bright light divided
equally between morning and evening were all equally effective in treating
patients with SAD.
In an uncontrolled study we showed that increasing the environmental light
had significant antidepressant effects in 6 children and adolescents with
SAD. In further studies we are continuing to explore the formal properties
of light treatment in SAD.
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NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER
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批准号:4696480
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
SEROTONERGIC ABNORMALITIES IN SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:6162924
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:6162940
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:3781365
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:3880883
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
ANTIDEPRESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER AND NORMAL CONTROL
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批准号:3880882
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
CLINICAL ASPECTS OF WINTER SEASONAL AFFECTIVE DISORDER
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批准号:3845394
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
CLINICAL ASPECTS OF WINTER SEASONAL AFFECTIVE DISORDER
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批准号:2578777
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
EFFECTS OF LIGHT IN HIV PATIENTS
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批准号:3859920
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
SEROTONERGIC ABNORMALITIES IN SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:6111189
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
ANTIDEPARESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER AND NORMAL CONTRO
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批准号:3944723
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
STUDY OF THE EFFECTS OF LIGHT AND TRIAZOLAM ON DELAYED SLEEP PHASE SYNDROME
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批准号:3921943
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
ANTIDEPRESSANT EFFECTS OF LIGHT IN WINTER SEASONAL AFFECTIVE DISORDER
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批准号:3845256
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
ANTIDEPRESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER AND NORMAL CONTROL
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批准号:3900973
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER (SAD) AND LIGHT THERAPY
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批准号:5203855
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
CLINICAL ASPECTS OF WINTER SEASONAL AFFECTIVE DISORDER (SAD)
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批准号:3759526
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
ANTIDEPRESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER
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批准号:3781398
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
SYMPATHETIC NERVOUS SYSTEM AND HPA AXIS PROCESSES IN SEASONAL AFFECTIVE DISORDER
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批准号:3759544
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:3845219
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
SEROTONERGIC ABNORMALITIES IN SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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批准号:2578820
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:N E ROSENTHAL
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依托单位:
海外基金