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NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY

NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
季节性情感障碍的神经生物学和光疗法
批准号：
6162940
负责人：
N E ROSENTHAL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6162940
关键词：
G protein body temperature regulation circadian rhythms clinical research hemoglobin human subject human therapy evaluation hypothalamic pituitary axis neurobiology photobiology phototherapy pituitary adrenal axis prolactin seasonal affective disorder serotonin visible light

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英文摘要
In our ongoing studies of the hypothalmo-pituitary-adrenal (HPA) axis in SAD, we have analyzed data from a graded treadmill exercise test, which acts as a naturalistic stressor to the HPA axis. We have measured ACTH, cortisol, catecholamine, and growth hormone secretion in response to this challenge. Results suggest abnormal HPA-axis functioning in SAD patients, as evidenced by exaggerated ACTH secretion and blunted norepinephrine secretion in response to stress. These abnormalities were normalized during the summer. Our study of circadian systems has focused upon winter and summer patterns of nocturnal melatonin secretion in patients with SAD and healthy controls. These studies are reported by Dr. Thomas Wehr of the Clinical Psychobiology Branch in his report Z01 MH 02739-02 CP.
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会议论文
ANTIDEPRESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER AND NORMAL CONTROL
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER
CLINICAL ASPECTS OF WINTER SEASONAL AFFECTIVE DISORDER
NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY
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