NEUROBIOLOGY OF SEASONAL AFFECTIVE DISORDER AND LIGHT THERAPY

季节性情感障碍的神经生物学和光疗法

• 批准号: 6162940
• 负责人: N E ROSENTHAL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162940
• 关键词: G protein; body temperature regulation; circadian rhythms; clinical research; hemoglobin; human subject; human therapy evaluation; hypothalamic pituitary axis; neurobiology; photobiology; phototherapy; pituitary adrenal axis; prolactin; seasonal affective disorder; serotonin; visible light

In our ongoing studies of the hypothalmo-pituitary-adrenal (HPA) axis in SAD, we have analyzed data from a graded treadmill exercise test, which acts as a naturalistic stressor to the HPA axis. We have measured ACTH, cortisol, catecholamine, and growth hormone secretion in response to this challenge. Results suggest abnormal HPA-axis functioning in SAD patients, as evidenced by exaggerated ACTH secretion and blunted norepinephrine secretion in response to stress. These abnormalities were normalized during the summer. Our study of circadian systems has focused upon winter and summer patterns of nocturnal melatonin secretion in patients with SAD and healthy controls. These studies are reported by Dr. Thomas Wehr of the Clinical Psychobiology Branch in his report Z01 MH 02739-02 CP.

在我们正在进行的研究下丘脑-垂体-肾上腺（HPA）轴在