HISTOPATHOLOGY AND DIETARY PROTEIN IN HYPERTENSION

观察了10个月内肾脏和心脏的形态学变化 老年易卒中自发性高血压大鼠（SHRSP）， 维持九个月的三个实验饮食之一：标准 (STD 25.3%粗蛋白和0.5%蛋氨酸），低蛋白（LP：19%粗蛋白 蛋白质和0.39%蛋氨酸）或高蛋氨酸（MET：25.3%粗蛋白质 和2.0%甲硫氨酸）。除24周龄和40周龄外，SHRSP/LP 血压明显低于SHRSP/STD和SHRSP/LP。 在整个实验中，血压正常的Wistar京都大鼠喂食标准饮食 (WKY/STD）维持显著低于SHRSP组的血压。从4 至10月龄，SHRSP/STD和SHRSP/LP分别为25%~ 63%和46%~ 80%， 分别）表现出异常行为，包括兴奋， 重复抬起、过度兴奋和爪子粗颤。10时 月龄时，心肌肥厚和纤维化程度、增厚 的心肌内小动脉和炎性细胞的存在， 三个实验SHRSP组之间相似。SHRSP/LP的肾脏 显示血管壁明显增厚， 小动脉管腔和肾小球硬化。由于形态学的 SHRSP/MET的肾脏与SHRSP/STD的肾脏有显著差异， 似乎接近SKY/STD，从这些结果来看， 增加饮食中蛋氨酸的量提供了保护， SHRSP高血压的肾脏并发症;然而， 需要进行调查，以确定这种保护措施是否 主要是由于饮食对血压的影响或饮食的影响 一些代谢变化，减缓组织损伤的速度和程度， 长期高血压

Studies were made of the morphology of the kidney and heart in 10-month old, stroke-prone spontaneously hypertensive rats (SHRSP) which had been maintained for nine months on one of three experimental diets: standard (STD; 25.3% crude protein and 0.5% methionine), low protein (LP: 19% crude protein and 0.39% methionine), or high methionine (MET: 25.3% crude protein and 2.0% methionine). Except for 24 and 40 weeks of age, SHRSP/LP had significantly lower blood pressure than those of SHRSP/STD and SHRSP/LP. Throughout the experiment, normotensive Wistar Kyoto rats fed standard diet (WKY/STD) maintained significantly lower BP than the SHRSP groups. From 4 to 10 months of age, SHRSP/STD and SHRSP/LP (25% - 63% and 46% - 80%, respectively) exhibited abnormal behavior which included excitement, repetitive lifting, hyperirritability and coarse tremor of the paws. At 10 months of age, the degree of cardiac hypertrophy and fibrosis, thickening of intramyocardial arterioles and the presence of inflammatory cells were similar among the three experimental SHRSP groups. The kidneys of SHRSP/LP demonstrated marked thickening of the vascular walls, narrowing of the lumina of arterioles, and glomerular sclerosis. Since the morphology of the kidneys from SHRSP/MET differed markedly from that of SHRSP/STD but appeared close to that of SKY/STD, it seems from these results that increasing the amount of methionine in the diet provides protection against the renal complications of hypertension in SHRSP; however, further investigation is required to determine whether this protective action is primarily a result of dietary effect on blood pressure or dietary influence on some metabolic changes that slow the rate and degree of tissue damage in prolonged hypertension.