BIOCHEMISTRY OF THE SPONTANEOUSLY HYPERTENSIVE RATS

自发性高血压大鼠的生物化学

基本信息

项目摘要

Membrane fractions enriched in sarcoplasmic reticulum (SR) were isolated from the cardiac ventricles of 10-month-old, stroke-prone spontaneously hypertensive rats (SHRSP) which had been maintained for nine months on one of four experimental diets: low protein (LP) (19% protein), standard (STD) (24% protein), high protein (HP) (32% protein), or high methionine (1.9% methionine) (MET). ATPase activities, as well as ATP-dependent Ca2+ binding and Ca2+-uptake activities, of the isolated SR were determined to examine the influence of diet on myocardial Ca2+-pump activity. SR from all four groups exhibited similar Mg2+-ATPase activity. However, the (Ca2+ + Mg2+)-ATPase activity was significantly elevated in SR from rats on the MET diet while the activity in the other groups showed no significant differences. After 15 sec of incubation, Ca2+- uptake (presence of oxalate) in SR from the LP group was significantly less than Ca2+-uptake in SR from each of the three other diet groups. Ca2+ binding (absence of oxalate) in the SR from the LP group was also significantly less than that from each of the three other diet groups. Kinetic analysis of SR Ca2+-uptake over 60 sec revealed that the Bmax of the MET group was significantly higher than Bmax of the STD diet group. In addition, the Bmax of the LP group was significantly lower than Bmax of the HP and MET groups. There was no significant difference in affinity of the SR Ca2+-uptake system among the four diet groups. These results indicate that modification of dietary protein can influence myocardial SR Ca2+-pump function.
分离出富含肌浆网(SR)的膜组分

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

M DIOLULU其他文献

M DIOLULU的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('M DIOLULU', 18)}}的其他基金

HISTOPATHOLOGY AND DIETARY PROTEIN IN HYPERTENSION
高血压的组织病理学和膳食蛋白质
  • 批准号:
    3899215
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
HEMODYNAMICS AND DIETARY PROTEIN IN HYPERTENSION
高血压的血流动力学和膳食蛋白质
  • 批准号:
    3920135
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
DIETARY PROTEIN & DEFECT IN VASCULAR SMOOTH MUSCLE CONTRACTILITY IN HYPERTENSION
膳食蛋白质
  • 批准号:
    3942896
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOCHEMICAL CHANGES IN HEARTS OF HYPERTENSIVE RATS FOLLOWING DIETARY PROTEINS
膳食蛋白质摄入后高血压大鼠心脏的生化变化
  • 批准号:
    3966603
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

The role of antihypertensive agents in renal and vascular complications in a model of hypertension and diabetes
抗高血压药物在高血压和糖尿病模型中肾脏和血管并发症中的作用
  • 批准号:
    nhmrc : 145854
  • 财政年份:
    2001
  • 资助金额:
    --
  • 项目类别:
    NHMRC Postgraduate Scholarships
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
  • 批准号:
    6125791
  • 财政年份:
    1997
  • 资助金额:
    --
  • 项目类别:
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
  • 批准号:
    2487342
  • 财政年份:
    1997
  • 资助金额:
    --
  • 项目类别:
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
  • 批准号:
    2839029
  • 财政年份:
    1997
  • 资助金额:
    --
  • 项目类别:
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
  • 批准号:
    6330091
  • 财政年份:
    1997
  • 资助金额:
    --
  • 项目类别:
ANTIHYPERTENSIVE AGENTS FROM RANUNCULACEAE
毛茛科抗高血压药
  • 批准号:
    2217036
  • 财政年份:
    1993
  • 资助金额:
    --
  • 项目类别:
ANTIHYPERTENSIVE AGENTS FROM RANUNCULACEAE
毛茛科抗高血压药
  • 批准号:
    3343932
  • 财政年份:
    1993
  • 资助金额:
    --
  • 项目类别:
ANTIHYPERTENSIVE AGENTS FROM RANUNCULACEAE
毛茛科抗高血压药
  • 批准号:
    2217037
  • 财政年份:
    1993
  • 资助金额:
    --
  • 项目类别:
CANNABINOIDS AS ANTIHYPERTENSIVE AGENTS
大麻素作为抗高血压药
  • 批准号:
    3500707
  • 财政年份:
    1985
  • 资助金额:
    --
  • 项目类别:
Antihypertensive Agents of Kudzu: Possible Chemical Utilization of a Southeastern Pest Vine
葛根的抗高血压剂:东南部害虫藤蔓的可能化学利用
  • 批准号:
    7905238
  • 财政年份:
    1979
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了