BIOCHEMISTRY OF THE SPONTANEOUSLY HYPERTENSIVE RATS
自发性高血压大鼠的生物化学
基本信息
- 批准号:4694551
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:adenosinetriphosphatase antihypertensive agents blood vessel disorder calcium metabolism cardiovascular disorder prevention cardiovascular pharmacology dietary proteins dietary supplements disease /disorder model disease /disorder proneness /risk histopathology hypertension methionine molecular pathology myocardium nutrition related tag plethysmography sarcoplasmic reticulum stroke
项目摘要
Membrane fractions enriched in sarcoplasmic reticulum (SR) were isolated
from the cardiac ventricles of 10-month-old, stroke-prone spontaneously
hypertensive rats (SHRSP) which had been maintained for nine months on one
of four experimental diets: low protein (LP) (19% protein), standard (STD)
(24% protein), high protein (HP) (32% protein), or high methionine (1.9%
methionine) (MET). ATPase activities, as well as ATP-dependent Ca2+
binding and Ca2+-uptake activities, of the isolated SR were determined to
examine the influence of diet on myocardial Ca2+-pump activity. SR from
all four groups exhibited similar Mg2+-ATPase activity. However, the (Ca2+
+ Mg2+)-ATPase activity was significantly elevated in SR from rats on the
MET diet while the activity in the other groups showed no significant
differences. After 15 sec of incubation, Ca2+- uptake (presence of
oxalate) in SR from the LP group was significantly less than Ca2+-uptake in
SR from each of the three other diet groups. Ca2+ binding (absence of
oxalate) in the SR from the LP group was also significantly less than that
from each of the three other diet groups. Kinetic analysis of SR
Ca2+-uptake over 60 sec revealed that the Bmax of the MET group was
significantly higher than Bmax of the STD diet group. In addition, the
Bmax of the LP group was significantly lower than Bmax of the HP and MET
groups. There was no significant difference in affinity of the SR
Ca2+-uptake system among the four diet groups. These results indicate that
modification of dietary protein can influence myocardial SR Ca2+-pump
function.
分离出富含肌浆网(SR)的膜组分
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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M DIOLULU其他文献
M DIOLULU的其他文献
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{{ truncateString('M DIOLULU', 18)}}的其他基金
DIETARY PROTEIN & DEFECT IN VASCULAR SMOOTH MUSCLE CONTRACTILITY IN HYPERTENSION
膳食蛋白质
- 批准号:
3942896 - 财政年份:
- 资助金额:
-- - 项目类别:
BIOCHEMICAL CHANGES IN HEARTS OF HYPERTENSIVE RATS FOLLOWING DIETARY PROTEINS
膳食蛋白质摄入后高血压大鼠心脏的生化变化
- 批准号:
3966603 - 财政年份:
- 资助金额:
-- - 项目类别:
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