HEMODYNAMICS AND DIETARY PROTEIN IN HYPERTENSION

高血压的血流动力学和膳食蛋白质

• 批准号: 3920135
• 负责人: M DIOLULU
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920135
• 关键词: blood pressure; dietary proteins; hemodynamics; hypertension; laboratory rat; methionine; nutrition related tag; spontaneous hypertensive rat; vascular resistance

Hemodynamic variables were evaluated in 4-month-old normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive stroke-prone rats (SHRSP) that had been maintained for 3 months on one of four experimental diets, standard (STD: 24% crude protein), low protein (LP; 19% crude protein), high protein (HP; 32% crude protein), or high methionine (Met; 1.9% methionine). WKY/STD and SHRSP/LP had similar body weights (BW) that were significantly higher than those of SHRSP/STD, SHRSP/HP and SHRSP/Met. The heart weights (HW) of SHRSP/LP were significantly higher than those of the other experimental groups. The HW/BW ratio for WKY/STD was significantly less than that for any of the SHRSP groups, while the HW/BW ratio for SHRSP/LP was significantly higher than that for SHRSP/HP and SHRSP/Met. The systolic blood pressure (BPs) of all SHRSP groups was significantly higher than that of WKY/STD, while the BPs of SHRSP/STD was significantly higher than that of SHRSP/Met, SHRSP/HE and SHRSP/LP. The diastolic blood pressures (BPd) of WKY/STD, SHRSP/Met and SHRSP/HP were the same but significantly lower than those of SHRSP/STD and SHRSP/LP. WKY/STD and SHRSP/Met groups had similar mean arterial pressures (MAP) that were significantly lower than those of SHRSP/HP, SHRSP/STD and SHRSP/LP. The relative total peripheral resistance (TPR) in WKY/STD, SHRSP/Met and SHRSP/HP was similar but significantly lower than that of SHRSP/STD and SHRSP/LP. The results of these experiments indicate that the increased MAP in SHRSP fed either a standard rat diet or a low protein diet was due to increased TPR, while a high protein diet led to nearly normal MAP due to a reduction in TPR.

在4个月大的正常血压儿童中评价血流动力学变量。 Wistar京都大鼠（WKY）和自发性高血压卒中倾向 大鼠（SHRSP）已维持3个月的四个之一 实验日粮，标准（STD：24%粗蛋白），低蛋白 (LP; 19%粗蛋白），高蛋白（HP; 32%粗蛋白），或 高蛋氨酸（Met; 1.9%蛋氨酸）。 WKY/STD和SHRSP/LP 相似的体重（BW）显著高于 SHRSP/STD、SHRSP/HP和SHRSP/Met. 心脏重量（HW） SHRSP/LP显著高于其他各组 实验组。 WKY/STD的HW/BW比显著高于对照组， 低于任何SHRSP组，而HW/BW比 SHRSP/LP组显著高于SHRSP/HP组， SHRSP/Met. SHRSP各组的收缩压（BP）分别为 显著高于WKY/STD，而 SHRSP/STD组与SHRSP/Met组、SHRSP/HE组比较，差异有显著性（P <0.05 和SHRSP/LP。 WKY/STD的舒张压（BPd）， SHRSP/Met和SHRSP/HP相同，但显著低于 SHRSP/STD和SHRSP/LP。 WKY/STD组和SHRSP/Met组 相似的平均动脉压（MAP）， 与SHRSP/HP、SHRSP/STD和SHRSP/LP相比， 相对总 WKY/STD、SHRSP/Met和SHRSP/HP的外周阻力（TPR）分别为 与SHRSP/STD相似，但显著低于SHRSP/STD， SHRSP/LP。 这些实验的结果表明， 增加MAP在SHRSP喂养无论是标准的大鼠饮食或低 蛋白质饮食是由于增加TPR，而高蛋白质饮食 由于TPR降低，导致MAP几乎正常。