RADIATION THERAPY WITH RADIOLABELLED ANTIBODIES--TECHNICAL ASPECTS AND DOSIMETRY

放射性标记抗体的管理是一个相对较新的治疗方法 治疗某些癌症的方式。这个领域的大部分是发展性的 在自然界中。特别是，肿瘤块的剂量测定，特别是在 微观层面，尚不清楚。辐射物理与计算机 自动化科正积极协助实施临床 协议.目前的研究主要集中在两个方面。 在时间的基础上对器官特异性分布模式进行成像， 这是理解抗体动力学的基础， 辐射剂量测定法（在整个器官水平）。能够准确 利用核医学成像技术定位生物分布模式 并且为了相对于其它成像精确地配准这些图像 常规医学检查（CT或MRI）对于获得定量结果至关重要。 显微镜下肿瘤块的剂量测定是通过使用 计算机模拟在可能的情况下，将使用 定量放射自显影

Administration of radiolabelled antibodies is a relatively new treatment modality for certain forms of cancer. Much of this field is developmental in nature. In particular, the dosimetry of tumor masses, especially at the microscopic level, is at yet unknown. The Radiation Physics and Computer Automation Section is actively assisting in the implementation of clinical protocols. Current research is in two major areas. Imaging of the organ-specific distribution patterns on a temporal basis is fundamental to the understanding of antibody kinetics and for large volume radiation dosimetry (at the total organ level). The ability to accurately localize biodistribution patterns using nuclear medicine imaging techniques and to accurately register these images with respect to other imaging modalities (CT or MRI) is essential for obtaining quantitative results. Dosimetry of microscopic tumor masses is approached through the use of computer modeling. The results, where possible, will be validated using quantitative autoradiography.