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ANALYSIS OF AN PROTO-ONCOGENE ENCODING A PUTATIVE GROWTH FACTOR RECEPTOR

ANALYSIS OF AN PROTO-ONCOGENE ENCODING A PUTATIVE GROWTH FACTOR RECEPTOR
编码假定生长因子受体的原癌基因的分析
批准号：
3916872
负责人：
S A AARONSON
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916872
关键词：
DNA cytokine receptors gel electrophoresis growth factor receptors molecular cloning natural gene amplification neoplastic cell neoplastic transformation nucleic acid hybridization oncogenes platelet derived growth factor protein tyrosine kinase protooncogene sarcoma

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英文摘要
Using cloned v-fms or mouse platelet-derived growth factor receptor cDNA as a probe, we have isolated genomic DNA clones homologous to the proto-oncogene family. A novel putative kinase receptor gene has been identified and characterized by cDNA cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and share a common pattern of cystreine distribution which is seen in the receptors for platelet-derived growth factor (PDGF) and colony stimulating factor (CSF-1). This new gene is overexpressed in several human sarcoma cells, suggesting that this gene may be involved in the neoplastic process of some tumors.
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