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CHARACTERIZATION OF THE GENE PRODUCTS OF THE ERG (ETS-RELATED GENE) LOCUS

CHARACTERIZATION OF THE GENE PRODUCTS OF THE ERG (ETS-RELATED GENE) LOCUS
ERG（ETS 相关基因）基因座基因产物的表征
批准号：
3916918
负责人：
T S PAPAS
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916918
关键词：
antibody formation antiserum bacteria gene expression methionine nucleic acid probes nucleic acid sequence protein biosynthesis protein sequence radiotracer synthetic peptide tissue /cell culture

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英文摘要
The presence of putative erq proteins encoded by the erq (ets- related gene) locus has been examined in specific human cell lines. To probe the erq proteins, polyclonal antisera have been prepared against synthetic polypeptides representing amino acid sequences deduced from the DNA sequence of the erg gene locus. Furthermore, we have to facilitate further analysis of the putative erg proteins; we have purified a bacterially expressed erg protein and are using this highly purified protein to raise polyclonal erg antiserum. In immunoprecipitates from the nuclear fractions of 35S-methionine-labeled COLO 320 cells we detect two proteins of 56 and 63 Kd which reacted specifically with the specific erg-RI antiserum. Whether these proteins represent the cellular erq gene products is currently under investigation.
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会议论文
EXPRESSION OF HTLV-III ENVELOPE GENE IN EUKARYOTIC (SV40)-BASED EXPRESSION VECTOR
ROLE OF ETS1 IN LYMPHOID CELLS
C-ETS GENE EXPRESSION DURING CELL PROLIFERATION AND DIFFERENTIATION
CELLULAR FUNCTION AND REGULATION OF ETS PROTEINS
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