THE POPULATION GENETICS OF TRANSPOSABLE ELEMENTS

转座元件的群体遗传学

• 批准号: 3918714
• 负责人: C H LANGLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918714
• 关键词: Drosophilidae; animal population genetics; biochemical evolution; chromosome aberrations; chromosome translocation; evolution; gene expression; gene frequency; genetic recombination; sex chromosomes; transposon /insertion element

The main goal of this project is to study the population biology of transposable genetic elements (parasites of the genome) using Drosophila as a model system in conjunction with quantitative theoretical analysis. During this period, the research has focused on two topics: 1) What is the primary mechanism containing the numbers of transposable elements? and 2) Is the evolutionary diversity observed between copies of elements at the DNA sequence level consistent with quantitative models of the dynamics of the elements in natural populations? Work over the last several years in this laboratory have led to the hypothesis that unequal crossing over is an important mechanism in the containment of transposable elements. The theoretical analysis of this model were examined. Ongoing research concerns the rate of occurrence of such events. A large number of spontaneous chromosomal deletions have been collected and the breakpoints are being characterized at the DNA sequence level to confirm the role of crossing over between transposable elements. The cloning and DNA sequencing of copies of the transposable element hobo from sampled individuals, populations and species is ongoing.

这个项目的主要目标是研究种群生物学 转座基因元件（基因组的寄生虫）， 果蝇作为模型系统与定量 理论分析 在此期间，研究重点 关于两个主题：1）什么是包含 转座因子的数量2）进化论 在DNA序列的元件拷贝之间观察到的多样性 水平一致的定量模型的动态 自然人群中的元素？ 过去几年的工作 在这个实验室里，已经导致了一个假设， over是包含转座基因的重要机制 元素 对该模型进行了理论分析。 正在进行的研究关注此类事件的发生率。 大量的自发性染色体缺失已经被发现。 收集和断裂点正在表征的DNA 序列水平，以确认交叉之间的作用 转座因子 拷贝的克隆和DNA测序 转座因子流浪汉的样本， 种群和物种正在进行中。