MOLECULAR GENETIC VARIATION IN NATURAL POPULATIONS

自然群体中的分子遗传变异

• 批准号: 3918720
• 负责人: C H LANGLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918720
• 关键词: Drosophilidae; alcohol dehydrogenase; biological polymorphism; cytogenetics; gene duplication; gene frequency; heavy metals; metal poisoning; metallothionein; molecular genetics; natural selections; nucleic acid sequence; population genetics

The primary focus of this project is the investigation of the relative roles of mutation, recombination, genetic drift and natural selection in shaping the levels of genetic variation observed at the DNA level. Specific experiments look for evidence of migration and population subdivision in the geographic distribution of DNA sequence variation at the Adh locus in Drosophila melanogaster. Several experiments address the fundamental question: what is the quantity and quality of molecular population genetic variation? To obtain a general answer many loci (White, yellow to achete, g-6-phd, forked, vermilion, suppressor of forked and forked) in natural populations of Drosophila have been surveyed. A specific question in these and comparative studies with other species is the consequence of large differences in the amounts of crossing over per kilobase on the molecular genetic variation. The hypothesis that environmental heavy metals have selected for duplication of the metallothionein gene in natural populations is being tested by comparing the frequencies of these variants in locations with large differences in lead and cadmium pollution.

该项目的主要重点是调查 突变、重组、遗传漂变和 自然选择塑造了遗传变异的水平 在DNA水平上观察。 具体实验寻找证据 地理上的移民和人口细分 Adh基因座DNA序列变异的分布 果蝇 几个实验解决了 基本问题：分子的数量和质量是什么 群体遗传变异？ 为了得到一个普遍的答案， （白色，黄色至刺红色，g-6-phd，分叉，朱红，抑制 在果蝇的自然种群中， 被调查。 在这些具体问题和比较 与其他物种的研究是巨大差异的结果 分子上的过氧化物酶的交换量 遗传变异 环境重金属污染的假说 选择复制金属硫蛋白基因， 自然种群正在通过比较 这些变异体的位置与铅和 镉污染