长期服用胺碘酮对心脏功能的影响-猫眼课题宝

长期服用胺碘酮对心脏功能的影响

批准号：

3920096

负责人：

M E MITCHELL

金额：

$0.0万

依托单位：

NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3920096

关键词：

cardiotoxin coronary vasodilator drug adverse effect heart contraction heart function heart rate heart surgery laboratory rat mathematical model spontaneous hypertensive rat

中文摘要

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英文摘要

Low cardiac output syndrome has been reported after cardiac surgery in patients who have received chronic amiodarone administration. To test for possible cardiac toxicity of amiodarone, the isolated working heart model was used. Chronic administration of amiodarone resulted in decreased heart rate and contractility in normal rats. Spontaneously hypertensive rats which received the drug had decreased heart rate, aortic output, and coronary flow compared to age/sex matched controls prior to ischemia. The conclusions were that chronic administration of amiodarone to normal rats caused a significant decrease in post-ischemia performance. Hypertrophied rat hearts are similarly sensitive to the drug.

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