EFFECTS OF CHRONIC AMIODARONE ADMINISTRATION ON CARDIAC FUNCTION

长期服用胺碘酮对心脏功能的影响

• 批准号: 3920096
• 负责人: M E MITCHELL
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920096
• 关键词: cardiotoxin; coronary vasodilator; drug adverse effect; heart contraction; heart function; heart rate; heart surgery; laboratory rat; mathematical model; spontaneous hypertensive rat

Low cardiac output syndrome has been reported after cardiac surgery in patients who have received chronic amiodarone administration. To test for possible cardiac toxicity of amiodarone, the isolated working heart model was used. Chronic administration of amiodarone resulted in decreased heart rate and contractility in normal rats. Spontaneously hypertensive rats which received the drug had decreased heart rate, aortic output, and coronary flow compared to age/sex matched controls prior to ischemia. The conclusions were that chronic administration of amiodarone to normal rats caused a significant decrease in post-ischemia performance. Hypertrophied rat hearts are similarly sensitive to the drug.

心脏手术后出现低心输出量综合征已有报道 在接受慢性胺碘酮治疗的患者中 局 为了测试可能的心脏毒性， 胺碘酮，采用离体工作心脏模型。 胺碘酮长期给药导致心脏功能下降 正常大鼠的心率和收缩力。 自发 接受该药物的高血压大鼠心率降低， 与年龄/性别匹配的主动脉输出量和冠状动脉流量相比 缺血前的对照。 结论是， 对正常大鼠给予胺碘酮引起显著的 缺血后性能下降。 肥大大鼠心脏 对药物同样敏感。