MYOCARDIAL PRESERVATION WITH PROSTAGLANDIN BX

使用前列腺素 BX 保护心肌

• 批准号: 3920109
• 负责人: M E MITCHELL
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920109
• 关键词: chemical condensation; heart preservation; laboratory rat; mitochondrial membrane; myocardial ischemia /hypoxia; oxidative phosphorylation; prostacyclins

Prostoglandin Bx (PGBx) is an oligmer of Prostaglandin Bl. The dimer and trimer have been shown to protect various tissues, including hepatic, renal, cerebral, and cardiac, from loss of function after ischemia. It is thought that the drug stabilizes mitochondrial membranes, and protects the mitochondria from loss of oxidative phosphorylation. A total of 85 rat hearts have been given Prostaglandin Bx (PGBx) during ischemia while on the isolated heart apparatus. Each heart received between 40-200 micrograms of PGBx, either at the beginning of the ischemic interval or at the time of reperfusion. The ischemic time was 27 minutes at 37.5 degrees C. The control group received no PGBx. Forty-six percent of the control hearts survived the ischemic period. The treated hearts had survival rates ranging from 38% to 100%. The difference was significant in only one of the treated groups. There were no differences in the percent recovery of systolic pressure, aortic flow, cardiac output or stroke volume between the control and treated groups. The treated animals had a significantly lower recovery of heart rate compared to the treated animals. The conclusion was that PGBx had little if any myocardial protective effect.

前列腺素Bx（PGBx）是前列腺素Bl的寡聚体。 的 二聚体和三聚体已经显示出保护各种组织， 包括肝脏、肾脏、大脑和心脏， 缺血后的功能。 据认为，药物稳定 线粒体膜，并保护线粒体免受损失 氧化磷酸化反应 用前列腺素Bx（PGBx）处理85只大鼠心脏， 在局部缺血期间，同时在离体心脏器官上。 每个心脏 接受40-200微克的PGBx，无论是在开始 缺血间隔或再灌注时。 的 缺血时间为27分钟，37.5 ℃。 对照组 没有收到PGBX。 46%的对照心脏存活了下来 缺血期。 接受治疗的心脏的存活率 从38%到100%。 只有一种差异是显著的， 治疗组。 在百分比上没有差异 收缩压、主动脉流量、心输出量或 对照组和治疗组之间的每搏输出量。 经处理的 动物的心率恢复明显低于 给治疗的动物。 结论是PGBx几乎没有 如果有心肌保护作用话。