MYOCARDIAL PRESERVATION WITH NICARPIDINE

用尼卡匹定保护心肌

• 批准号: 3920097
• 负责人: M E MITCHELL
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920097
• 关键词: cardiotonic agents; heart arrest; heart preservation; laboratory rat; myocardial ischemia /hypoxia; nonhuman therapy evaluation

To date approximately 50 rat hearts have been given cardioplegia containing nicardipine. It appears that nicardipine has a beneficial effect in protecting myocardium during ischemia at 37.5 degrees C, but not at 10 degrees C. The optimal dose of nicardipine for myocardial preservation has not yet been determined. These results are preliminary, and approximately 50 more animals will be required to complete the protocol.

迄今为止，大约有50只大鼠心脏被给予心脏停搏液 含有尼卡地平。 尼卡地平似乎 在37.5 ℃缺血期间保护心肌的有益作用 但不是在10摄氏度。 的最佳剂量 用于心肌保护的尼卡地平还没有 测定 这些结果是初步的，大约50 将需要更多的动物来完成该方案。