EFFECT OF COLLOID VERSUS CRYSTALLOID FLUID ADMIN. ON LUNG WATER DURING CPBP

胶体与晶体流体管理的效果。

• 批准号: 3942874
• 负责人: M E MITCHELL
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942874
• 关键词: body fluid balance therapy; body fluid osmolarity; colloids; coronary bypass; extracellular; human subject; human therapy evaluation; liquid crystal; postoperative complications; postoperative state; pulmonary edema; respiratory function

Forty adult patients undergoing elective surgical procedures requiring cardiopulmonary bypass will be studied in the perioperative period including the 24 hours immediately following operation. The hypotheses to be tested are: 1) measures of extravascular lung water and colloid osmotic pressure can be used to predict the postoperative clinical respiratory status of patients; and 2) the use of a colloid rather than a crystalloid solution for perioperative fluid resuscitation affects postoperative respiratory function and the need for respiratory support, hemodynamic variables, and cost. Possible adverse effects associated with either fluid resuscitation regimen will be determined.

40例接受择期手术的成人患者 需要体外循环的研究将在 围手术期包括紧随其后的24小时 手术。要检验的假设是：1)测量 可使用血管外肺水和胶体渗透压 预测手术后临床呼吸状态 患者；以及2)使用胶体而不是晶体 围手术期液体复苏方案对术后的影响 呼吸功能和对呼吸支持的需求， 血流动力学变量和成本。可能的不良影响 与任何一种液体复苏方案相关的是 下定决心。