EFFECT OF COLLOID VERSUS CRYSTALLOID FLUID ADMIN. ON LUNG WATER DURING CPBP

胶体与晶体流体管理的效果。

• 批准号: 3920091
• 负责人: M E MITCHELL
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920091
• 关键词: body fluid balance therapy; body fluid osmolarity; colloids; coronary bypass; extracellular; heart /lung bypass; human subject; human therapy evaluation; liquid crystal; postoperative complications; postoperative state; pulmonary edema; respiratory function

Forty adult patients undergoing elective surgical procedures requiring cardiopulmonary bypass will be studied in the perioperative period including the 24 hours immediately following operation. The hypotheses to be tested are: 1) measures of extravascular lung water and colloid osmotic pressure can be used to predict the postoperative clinical respiratory status of patients; and 2) the use of a colloid rather than a crystalloid solution for perioperative fluid resuscitation affects postoperative respiratory function and the need for respiratory support, hemodynamic variables, and cost. Possible adverse effects associated with either fluid resuscitation regimen will be determined.

40例接受择期外科手术的成人患者 需要心肺转流的研究将在 围手术期，包括术后24小时 操作 要检验的假设是：1）测量 可以使用血管外肺水和胶体渗透压 预测术后临床呼吸状态 患者; 2）使用胶体而非晶体 围手术期液体复苏影响解决方案 术后呼吸功能和呼吸的需要 支持、血流动力学变量和成本。 可能产生的不利影响 与任一液体复苏方案相关的 测定