PREDICTION OF ADVERSE EFFECTS OF AMIODARONE BY SIGNAL AVERAGING IN HCM PATIENTS

心电信号QRS波终末部分的分析 通过信号平均(SAE)来检测晚电位(LP)是一种 一种非侵入性识别易患皮肤病患者的方法 发展为室性心动过速(VT)，因此有发生 心源性猝死。我们早些时候已经表明，存在一个AND Lp存在与室性心动过速诱发率的相关性 肥厚型心肌病(HCM)患者。胺碘酮是一种 病人用抗心律失常药。现在的目的是 调查是为了确定SAE的变化是否可以预测 14例肥厚型心肌梗死患者的疗效和心律失常前电位 用胺碘酮。胺碘酮增加LP的发生率。这 与更容易诱发室性心动过速有关 在程序化电刺激过程中。因此，SAE可以识别 胺碘酮致心律失常的肥厚型心肌梗死患者 增加心源性猝死的风险。

Analysis of the terminal portion of the QRS of the ECG and detection of late potential (LP) by signal averaging (SAE) is a noninvasive method for identifying patients who are prone to develop ventricular tachycardia (VT) and are therefore at risk for sudden cardiac death. We have earlier shown that there was a and correlation between the presence of LP and inducibility of VT in patients with hypertrophic cardiomyopathy (HCM). Amiodarone is a patient antiarrhythmic drug. The purpose of the present investigation was to determine whether changes in SAE predicted efficacy and proarrhythmic potential in 14 HCM patients treated with amiodarone. Amiodarone increased the incidence of LP. This was associated with the greater ease with which VT was induced during programmed electrical stimulation. Thus SAE may identify HCM patients in whom amiodarone is proarrhythmic and may be at increased risk for sudden cardiac death.