PROGRAMMED STIMULATION FINDINGS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

肥厚型心肌病患者的程序刺激结果

• 批准号: 3920187
• 负责人: L FANANAPAZIR
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920187
• 关键词: electrocardiographic monitor; electrophysiology; heart disorder diagnosis; human subject; myocardium disorder; sudden cardiac death; syncope; tachycardia; ventricular fibrillation

The purpose of the present investigation was to determine the types of ventricular arrhythmias induced during programmed electrical stimulation (PES) and the relation of induced ventricular tachycardia to incidence to spontaneous arrhythmia and presenting symptoms in 95 patients with hypertrophic cardiomyopathy (HCM). Sustained VT was induced in 38 (40%) of patients. This consisted of rapid polymorphic VT in 60%, relatively slower monomorphic VT in 32% and ventricular fibrillation in 8% of patients. There was correlation between inducibility of VT and severity of presenting symptoms (sudden cardiac death more than syncope more than presyncope more than asymptomatic) and occurrence of VT on Holter monitoring. These findings suggest that PES truly identifies patients with cardiac electrical instability and severity of symptoms and presence of spontaneous VT may both be markers of this condition

本次调查的目的是确定 程序性电刺激诱发的室性心律失常 电刺激(PES)与诱发室性心动过速的关系 心动过速对自发性心律失常的发生率和表现 95例肥厚型心肌病(HCM)患者临床症状分析 38例(40%)患者发生持续性室速。这包括 60%的快速多形性VT，相对较慢的单形性VT 32%的患者和8%的患者发生室颤。曾经有过 室性心动过速的诱发性与临床表现严重程度的相关性 症状(心源性猝死多于晕厥 无症状晕厥前)与动态心电图上室速的发生 监控。这些发现表明，PES确实识别出 心脏电不稳定的患者和严重程度 症状和自发性室速的存在可能都是这种情况的标志 条件