PROTEIN SEQUENCER/AMINO ACID ANALYZER

脉冲液相蛋白质测序仪的研制 提出了一种灵敏的氨基酸分析仪和微孔高效液相色谱仪。 装备威斯塔尔的一个集中式蛋白质化学实验室 研究所。这套设备将在至少17年内发挥至关重要的作用 本建议书中所述的项目。在几个案例中 具体的项目代表蛋白质化学需求 相对较大的研究小组和这17个项目将 因此，直接或间接地受益于 在80名专业科研人员中约有一半 维斯塔尔研究所的成员。该设备的采购是 这是该研究所致力于开发现代化的 设施齐全，可提供必需蛋白质 化学服务和协作资源 生物医学问题。 该设施将在很大程度上通过按存储容量使用计费来自我维持 调查人员在第一年后。它将向所有人开放 Wistar研究所的潜在用户，优先考虑 本建议书中所述的用户组。这项提案的私家侦探 将承担起直接的行政和科学责任 这个设施。由用户组成的内部咨询委员会 和行政官员将帮助确定优先事项和 确保最大限度地利用此资源的策略。这个 维斯塔尔研究所的行政部门已经分配了空间，并已 做出了必要的员工承诺，以实现高效 这个设施的建立。该研究所还致力于 维护这些仪器以延长其使用寿命。

The acquisition of a pulsed liquid phase protein sequencer, high sensitivity amino acid analyser and a microbore HPLC is proposed to equip a centralized protein chemistry laboratory in the Wistar Institute. This equipment will be vitally important for at least 17 projects which are described in this proposal. In several cases specific projects represent the protein chemistry needs of relatively large research groups and these 17 projects will therefore directly or indirectly benefit the research efforts of about half of the 80 professional scientific research staff members of the Wistar Institute. Acquisition of this equipment is part of a major commitment of this institute to develop a modern fully equipped facility which can provide essential protein chemistry services and collaborative resources to diverse biomedical problems. The facility will be largely self-sustaining via charge backs to investigators after the first year. It will be available to all potential users at the Wistar Institute with priority given to the user groups described in this proposal. The P.I. of this proposal will assume direct administrative and scientific responsibility of the facility. An internal Advisory Committee comprised of users and administrative officials will aid in establishing priorities and policies to ensure maximum utilization of this resource. The administration of the Wistar Institute has allocated space and has made the necessary staff commitments for efficient establishment of this facility. The Institute is also committed to maintaining these instruments for their useful lifetime.