Acheiving instantaneous control of G-protein coupled receptors using light as a ligand

使用光作为配体实现 G 蛋白偶联受体的瞬时控制

基本信息

  • 批准号:
    G0801731/1
  • 负责人:
  • 金额:
    $ 49.69万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2009
  • 资助国家:
    英国
  • 起止时间:
    2009 至 无数据
  • 项目状态:
    已结题

项目摘要

The discovery and development of drugs that can influence human behaviour and physiology has played a crucial role in the huge advances in medicine that have occurred over the last century. However, future progress is likely to depend in large part upon our ability to overcome some of the inherent limitations in this pharmaceutical method for treating disease. A well known problem with using drugs is that of side effects, which occur because drugs commonly have effects on multiple parts of the body. Many otherwise effective drugs are lost because of the need to minimise such adverse effects. An additional problem with drugs is that, in comparison with the natural changes in our physiology that they hope to regulate, their effects build up rather slowly and can hang around for a long time. This contributes to our tendency to become desensitised to drugs and also stops them being used in conditions in which we would like more immediate and reversible effects. For these reasons, there is a pressing need to develop new ways of adjusting our physiology that go beyond the achievements of pharmacy. We propose developing such a technology. Our approach will be to modify a group of proteins called GPCRs to make them light sensitive. GPCRs appear in practically every cell of our body. Their job is to fine tune the cell?s activity and physiology according to signals released from neighbouring cells and other parts of the body. Because they are so influential they have long been recognised as a good way of treating the symptoms of disease. Indeed more than half of currently prescribed drugs are designed to alter their activity. By making GPCRs photosensitive, we will be able to use light rather than drugs to tweak their activity. Unlike drugs, light can be switched on and off very rapidly. Light can also be applied at high doses to a single group of cells without influencing the rest of the body. These features mean that we will be able to use the new GPCRs to achieve extremely fine tuned alterations in physiology way beyond what is currently possible using drugs. In the first instance we will use this technology in animal experiments that increase our knowledge of how common medical conditions (including obesity, depression and insomnia) come about. In time, it will become a completely new way of treating medical conditions.
能够影响人类行为和生理的药物的发现和开发在上个世纪发生的医学巨大进步中发挥了至关重要的作用。然而,未来的进展很可能在很大程度上取决于我们克服这种治疗疾病的药物方法的一些固有局限性的能力。使用药物的一个众所周知的问题是副作用,这是因为药物通常对身体的多个部位产生影响。许多其他有效的药物因为需要尽量减少这种副作用而丢失。药物的另一个问题是,与它们希望调节的我们生理上的自然变化相比,它们的效果建立得相当缓慢,并且可以持续很长时间。这导致我们倾向于对药物脱敏,也阻止了他们在我们希望更直接和可逆的效果的情况下使用。由于这些原因,迫切需要开发超越药学成就的新方法来调节我们的生理机能。我们建议开发这样的技术。我们的方法将是修改一组称为GPCR的蛋白质,使其对光敏感。GPCR几乎存在于我们身体的每个细胞中。他们的工作是微调细胞?根据邻近细胞和身体其他部位释放的信号来调节细胞的活动和生理。因为它们是如此有影响力,它们长期以来一直被认为是治疗疾病症状的好方法。事实上,目前超过一半的处方药是为了改变其活性。通过使GPCR具有光敏性,我们将能够使用光而不是药物来调整它们的活性。与药物不同,光可以非常迅速地打开和关闭。光也可以以高剂量应用于单个细胞群,而不会影响身体的其他部分。这些功能意味着我们将能够使用新的GPCR来实现非常精细的生理学改变,远远超出目前使用药物的可能性。首先,我们将在动物实验中使用这项技术,以增加我们对常见疾病(包括肥胖,抑郁和失眠)如何产生的知识。随着时间的推移,它将成为治疗疾病的一种全新方式。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Robert Lucas其他文献

Raising Voices not Dollars? The Effects of Citizens United on Political Efficacy
提高声音而不是美元?
Impact of particle morphology on abrasion, polishing and stain removal efficacy in a tooth cleaning model system
  • DOI:
    10.1016/j.biotri.2022.100218
  • 发表时间:
    2022-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    Changxiang Wang;Robert Lucas;Michael Milward;Paul R. Cooper
  • 通讯作者:
    Paul R. Cooper
Federal Reserve Bank of Minneapolis Research Department Staff Report 354 the Macroeconomics of Child Labor Regulation * Matthias Doepke Ucla and Federal Reserve Bank of Minneapolis
明尼阿波利斯联邦储备银行研究部工作人员报告 354 童工监管的宏观经济学 * Matthias Doepke Ucla 和明尼阿波利斯联邦储备银行
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fabrizio Zilibotti;Moshe Hazan;N. Kocherlakota;Dirk Krueger;Robert Lucas;Kiminori Matsuyama;Lee E Ohanian;Torsten Persson;Víctor Ríos;Richard Rogerson;Jean;Ken Sokoloff;N. Stokey
  • 通讯作者:
    N. Stokey
A nobel type of opsin with optogenetic potential: animal opsin-based photopigment as a potential dark-active and light-Inactivated G protein-coupled receptor
一种具有光遗传学潜力的诺贝尔类型视蛋白:动物视蛋白感光色素作为潜在的暗活性和光失活 G 蛋白偶联受体
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Takashi Nagata;Mitsumasa Koyanagi;Robert Lucas;Akihisa Terakita
  • 通讯作者:
    Akihisa Terakita
有袋類に着目した哺乳類の進化過程で失われた非視覚系光受容タンパク質の機能解析
哺乳动物进化过程中丢失的非视觉感光蛋白的功能分析,重点关注有袋动物
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Baoguo Shen;Takashi Nagata;Seiji Wada;Satomi Kamimura;Eriko Kage-Nakadai;Robert Lucas;Gebhard Schertler;Mitsumasa Koyanagi;Akihisa Terakita;小柳 光正,冨田 和志,清成 寛,寺北 明久
  • 通讯作者:
    小柳 光正,冨田 和志,清成 寛,寺北 明久

Robert Lucas的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Robert Lucas', 18)}}的其他基金

Italy-UK partnership: Understanding the neural networks underlying circadian decisions
意大利-英国合作伙伴关系:了解昼夜节律决策背后的神经网络
  • 批准号:
    BB/W018454/1
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Research Grant
Chronotype and circadian reafference: the impact of free will on the mammalian circadian clock
时间类型和昼夜节律重新影响:自由意志对哺乳动物生物钟的影响
  • 批准号:
    BB/V011111/1
  • 财政年份:
    2021
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Research Grant
The impact of daytime light exposure on diurnal and circadian rhythms in the diurnal rodent Rhabdomys pumillio
白天光照对日间啮齿动物横纹鼠昼夜节律的影响
  • 批准号:
    BB/P009182/1
  • 财政年份:
    2017
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Research Grant
Restoring vision in mouse models of retinal degeneration using human rod opsin.
使用人杆视蛋白恢复视网膜变性小鼠模型的视力。
  • 批准号:
    MR/N012992/1
  • 财政年份:
    2016
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Research Grant
Realising the optogenetic potential of JellyOp: an opsin photopigment from the box jellyfish
实现 JellyOp 的光遗传学潜力:来自箱形水母的视蛋白感光色素
  • 批准号:
    BB/K002252/1
  • 财政年份:
    2012
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Research Grant
The contribution of inner retinal photoreception to mouse visual function
视网膜内感光对小鼠视觉功能的贡献
  • 批准号:
    BB/I007296/1
  • 财政年份:
    2011
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Research Grant
Studies in Monetary Theory
货币理论研究
  • 批准号:
    9408649
  • 财政年份:
    1994
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Continuing Grant
NSF/ARPA Agreement for Use of ARPA VLSI Implementation
NSF/ARPA 使用 ARPA VLSI 实施协议
  • 批准号:
    9419682
  • 财政年份:
    1994
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Interagency Agreement
Studies in Distribution Theory
分配理论研究
  • 批准号:
    9109204
  • 财政年份:
    1991
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Continuing Grant
Studies in Monetary Economics
货币经济学研究
  • 批准号:
    8808835
  • 财政年份:
    1988
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Continuing Grant

相似海外基金

PFI-TT: Compact, Coherent, Hydrophone Array Systems for Real-Time, Instantaneous, Wide-Area, Ocean Acoustic Monitoring from Wind Farms and Other Ocean Platforms
PFI-TT:紧凑、相干、水听器阵列系统,用于风电场和其他海洋平台的实时、瞬时、广域海洋声学监测
  • 批准号:
    2345791
  • 财政年份:
    2024
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Standard Grant
Study on an estimation for instantaneous flow field in real river by data assimilation
数据同化估算真实河流瞬时流场的研究
  • 批准号:
    23K13410
  • 财政年份:
    2023
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Prediction of Instantaneous wall shear stress distribution through the fusion of Experimental/Computational/Data-driven Fluid Dynamics
通过融合实验/计算/数据驱动的流体动力学来预测瞬时壁剪应力分布
  • 批准号:
    22K18302
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Pioneering)
Instantaneous Tumor Spray for Real-Time Surgical Guidance
用于实时手术指导的瞬时肿瘤喷雾
  • 批准号:
    10681383
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
Fundamental study of an instantaneous adaptive point-like-scatterers-arrayed transcranial acoustic lens
瞬时自适应点状散射体阵列经颅声透镜的基础研究
  • 批准号:
    22K03987
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SWIFT: Instantaneous Feedback-based Adaptive Communications and Networks
SWIFT:基于即时反馈的自适应通信和网络
  • 批准号:
    2228974
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Standard Grant
Instantaneous Tumor Spray for Real-Time Surgical Guidance
用于实时手术指导的瞬时肿瘤喷雾
  • 批准号:
    10543617
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
Fundamental Processes of Instantaneous Structural Transformation of Crystal Defects Using Synergistic Effects of Irradiation Damage and Localized Laser Heating
利用辐照损伤和局部激光加热协同效应实现晶体缺陷瞬时结构转变的基本过程
  • 批准号:
    22K04783
  • 财政年份:
    2022
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Challenge to realize ultra-instantaneous annealing process for stretchable spin devices
实现可拉伸自旋器件超瞬时退火工艺的挑战
  • 批准号:
    21K18827
  • 财政年份:
    2021
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Towards reliable estimation of instantaneous pressure and aerodynamic loads from velocity measurements
通过速度测量可靠地估计瞬时压力和空气动力载荷
  • 批准号:
    RGPIN-2017-04222
  • 财政年份:
    2021
  • 资助金额:
    $ 49.69万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了