INHALATION CARCINOGENESIS OF ENVIRONMENTAL AGENTS

环境因素吸入致癌

• 批准号: 3095887
• 负责人: ARTHUR C UPTON
• 金额: $ 97.52万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3095887
• 关键词: carcinogenesis; chemical carcinogen; environment related neoplasm /cancer; inhalation drug administration; physical chemical interaction

This program project consists of five experimental projects: 1) the development of an animal model for the carcinogenesis of inhaled benzene will be attempted by treating rats and mice to various exposure regimes of benzene vapor and by combining exposure of benzene with known leukemogenic agents; 2) the development of an animal model for the carcinogenesis of inhaled arsenic compounds will be attempted by exposing rats to a combination of arsenic trioxide aerosol and sulfur dioxide and by intratracheally instilling the components of Bordeaux mixture into rats; 3) the effect of fiber length on asbestos carcinogenicity will be studied by exposing rats to two different lengths of asbestos fibers which have the same aerodynamic mass median diameters. The development of lung damage will be monitored in vivo during the course of the exposures: 4) the interaction of atmospheres of HCl plus HCHO with DNA will be studied by measuring DNA damage by means of the S-1 nuclease assay in skin and nasal epidermal cells, as well as bacteria; and, 5) the amount of BCME and other alkylating agents in known, tumorigenic atmospheres of HCl plus HCHO will be determined by gas chromatographic and mass spectrometric techniques.

本计划项目由五个实验项目组成：1）开发 将尝试建立吸入苯致癌的动物模型 通过对大鼠和小鼠进行各种苯蒸气暴露方式的治疗，并通过 将苯与已知的致白血病剂相结合； 2）发展 吸入砷化合物致癌的动物模型将 尝试将大鼠暴露于三氧化二砷气溶胶和 二氧化硫和气管内滴注波尔多成分 混合物注入大鼠体内； 3）纤维长度对石棉致癌性的影响 将通过将大鼠暴露于两种不同长度的石棉纤维来进行研究 具有相同的空气动力学质量中值直径。 肺的发育 在暴露过程中将监测体内损伤：4) 将研究 HCl 加 HCHO 气氛与 DNA 的相互作用 通过 S-1 核酸酶测定测量皮肤和鼻腔中的 DNA 损伤 表皮细胞以及细菌； 5) BCME 和其他的数量 已知的 HCl 加 HCHO 致瘤气氛中的烷化剂将 通过气相色谱和质谱技术测定。