CONTROL OF SODIUM AND POTASSIUM TRANSPORT BY THE NEPHRON

肾单位对钠和钾转运的控制

基本信息

项目摘要

The effects of atrial natriuretic factors (ANF) on cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) production by isolated renal tubules and glomeruli from rats has been investigated. ANF (1 micromolar) increased cGMP accumulation in isolated glomeruli 35-fold and in isolated inner medullary collecting ducts 20-fold. Small increases in cGMP accumulation were seen in response to 1 micromolar ANF in other nephron segments: proximal convoluted tubules, proximal straight tubules, thin descending limbs, medullary thick ascending limbs and cortical collecting ducts. Dose response studies revealed that the threshold for an increase in cGMP accumulation was 0.1-1 nanomolar ANF in inner medullary collecting ducts, and was 10-100 nanomolar in glomeruli. The threshold concentration for a response in inner medullary collecting ducts was approximately the same as reported circulating levels of ANF in control rats. ANF (1 micromolar) did not alter cAMP accumulation in the absence or presence of vasopressin in medullary thick ascending limbs or in inner medullary collecting ducts. Based on these results, we have initiated transport studies in isolated perfused inner medullary collecting ducts to determine whether ANF affects urea, water, or sodium chloride transport.
心钠素对环鸟苷的影响 环磷酸腺苷(cGMP)和环磷酸腺苷(cAMP)产生 用离体大鼠肾小管和肾小球进行了研究。 ANF(1 μ mol)增加离体肾小球cGMP的积累 35-内髓集合管20倍。 小 cGMP积累的增加被认为是对1微摩尔ANF的反应, 其他肾单位段:近曲小管,近端直管 小管,细的下降肢,髓质厚的上升肢, 皮质集合管 剂量反应研究表明, cGMP积累增加的阈值为0.1-1纳摩尔ANF, 内髓集合管,肾小球内10-100纳摩尔。 内髓集合反应的阈值浓度 导管与报告的ANF循环水平大致相同, 对照组大鼠。 ANF(1微摩尔)并不改变cAMP的积累, 在髓质厚的上升肢或在 内髓集合管 根据这些结果,我们有 在离体灌注的内髓收集中的起始转运研究 确定ANF是否影响尿素、水或氯化钠 运输

项目成果

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M A KNEPPER其他文献

M A KNEPPER的其他文献

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{{ truncateString('M A KNEPPER', 18)}}的其他基金

SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3942817
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3757626
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3843288
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
UREA TRANSPORT AND THE URINARY CONCENTRATING MECHANISM
尿素运输和尿液浓缩机制
  • 批准号:
    4694524
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
CONTROL OF SODIUM AND POTASSIUM TRANSPORT BY THE NEPHRON
肾单位对钠和钾转运的控制
  • 批准号:
    4694521
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3779530
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3858008
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
UREA TRANSPORT AND THE URINARY CONCENTRATING MECHANISM
尿素运输和尿液浓缩机制
  • 批准号:
    3966566
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3920033
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIA
肾上皮中的溶质和水运输
  • 批准号:
    3878929
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
心钠素和心脏代谢健康的调节:基因型引导的人类生理学研究
  • 批准号:
    10627996
  • 财政年份:
    2022
  • 资助金额:
    --
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Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
心钠素和心脏代谢健康的调节:基因型引导的人类生理学研究
  • 批准号:
    10419574
  • 财政年份:
    2022
  • 资助金额:
    --
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Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension
心房钠尿肽在盐敏感性高血压中的线粒体介导作用和治疗潜力
  • 批准号:
    10676800
  • 财政年份:
    2020
  • 资助金额:
    --
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Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension
心房钠尿肽在盐敏感性高血压中的线粒体介导作用和治疗潜力
  • 批准号:
    10442162
  • 财政年份:
    2020
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    --
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Mitochondria-Mediated Effects and Therapeutic Potential of Atrial Natriuretic Peptide in Salt-Sensitive Hypertension Diversity Supplement
盐敏感性高血压多样性补充剂中心房钠尿肽的线粒体介导作用和治疗潜力
  • 批准号:
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  • 财政年份:
    2020
  • 资助金额:
    --
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Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension
心房钠尿肽在盐敏感性高血压中的线粒体介导作用和治疗潜力
  • 批准号:
    10472035
  • 财政年份:
    2020
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Development of a high-precision diagnostic method for heart failure utilizing abnormal biosynthesis of beta-atrial natriuretic peptide in the failing heart
利用衰竭心脏中β-心房钠尿肽的异常生物合成开发心力衰竭的高精度诊断方法
  • 批准号:
    20K08414
  • 财政年份:
    2020
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    --
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    --
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