CONTROL OF SODIUM AND POTASSIUM TRANSPORT BY THE NEPHRON

肾单位对钠和钾转运的控制

• 批准号: 4694521
• 负责人: M A KNEPPER
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694521
• 关键词: arginine vasopressin; bicarbonates; bradykinin; desoxycorticosterone; hormone regulation /control mechanism; ion transport; kidney pharmacology; renal tubular transport; tissue /cell culture

The effects of mineralocorticoids, arginine vasopressin, and bradykinin on isolated perfused cortical collecting ducts from rats are being investigated. Chronic deoxycorticosterone treatment of the rats increases sodium absorption and potassium secretion by the collecting ducts in vitro. Addition of arginine vasopressin to the bath in vitro increases the rates of sodium, chloride, bicarbonate, and fluid absorption and the rate of potassium secretion. Addition of bradykinin to the bath in vitro inhibited the sodium and chloride absorption, but did not significantly affect potassium or bicarbonate transport, or the transepithelial potential difference. These results are consistent with the presence of an electroneutral NaCl transport process in rat cortical collecting ducts that is inhibited by bradykinin.

盐皮质激素、精氨酸加压素和缓激肽对血管紧张素转换酶的影响 分离的大鼠灌流皮质集合管正在被 调查过了。慢性脱氧皮质酮治疗大鼠增加 土壤中集合管对钠的吸收和钾的分泌 体外培养。在体外浴液中加入精氨酸加压素可增加 钠、氯、重碳酸盐和液体吸收率 钾的分泌量。缓激肽在体外浴液中的添加 抑制钠和氯的吸收，但不显著 影响钾或碳酸氢盐的转运，或跨血管上皮电位 不同。这些结果与 大鼠皮质集合管中电子中性盐的转运过程 被缓激肽抑制。