NEUROTOLOGY CLINICAL RESEARCH CENTER

神经病学临床研究中心

• 批准号: 3099326
• 负责人: HERMAN A. JENKINS
• 金额: $ 81.88万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-02-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099326
• 关键词: labyrinth

These Neuro-Otology Clinical Research Center efforts are conducted by a team of interrelated investigators who have worked together for several years. The Center focuses upon audiology, human auditory and vestibular function, animal auditory and vestibular function, morphology (both light and electron microscopy), auditory system neuroanatomy, and cellular biology--biochemistry as they relate to the pathophysiology of disorders of the senses of hearing and equilibrium. This multidisciplinary program of both clinical and basic research focuses upon the following objectives: (1) to develop and refine techniques for assessment of auditory disorders in children and adults, with emphasis on acoustic reflex, auditory brainstem response and behavioral correlates of central auditory disorders; (2) to study human auditory nerve action potential and auditory brainstem response to further our knowledge of peripheral auditory physiology and to develop electrophysiologic tests to quantify and localize hearing loss; (3) to evaluate the functional alterations after partial ablation of the vestibular system and the system's subsequent compensation--both direct measurements (electrophysiological analyses) and indirect measurements (degree of gait deviation) are used; (4) to study proprioceptive and visual input enhancement of vestibular system induced imbalance; (5) to assess morphological and cell biology--biochemical findings related to functional abnormalities; (6) to study acoustic reflex pathway both functionally and neuroanatomically; (7) to determine ultrastructure alteration in the vestibular ganglion after labyrinthectomy; and (8) to study electron microscopic findings of changes induced by ototoxic agents in developing chick embryo model. The central research theme is the fundamental study of neuro-otology and its related disorders.

这些神经耳科临床研究中心的工作是由一个团队进行， 他们是多年来一起工作的相互关联的调查人员。 的 中心专注于听力学，人类听觉和前庭功能，动物 听觉和前庭功能，形态学（包括光和电子 显微镜），听觉系统神经解剖学和细胞生物学-生物化学， 它们涉及听觉障碍的病理生理学， 均衡 这个临床和基础研究的多学科计划 重点是以下目标：（1）开发和完善技术， 评估儿童和成人的听觉障碍，重点是 听觉反射、听觉脑干反应和行为相关性 中枢性听觉障碍;（2）研究人类听神经动作电位 和听性脑干反应，以进一步了解外周听觉 生理学和发展电生理测试，以量化和定位 听力损失;（3）评估部分消融后的功能变化 前庭系统和该系统的后续补偿-都直接 测量（电生理分析）和间接测量（程度 步态偏差）;（4）研究本体感受和视觉输入 增强前庭系统引起的不平衡;（5）评估形态学 和细胞生物学--与功能异常有关的生化发现;（6） 从功能和神经解剖学角度研究声反射通路; 测定前庭神经节超微结构的变化， （8）电镜观察 在发育中的鸡胚模型中由耳毒性剂诱导。 中心的研究主题是神经耳科的基础研究及其 相关疾病。