Cell mediated immunity against RSV and influenza in a human experimental challenge model

人类实验攻击模型中细胞介导的针对 RSV 和流感的免疫

• 批准号: G0902266/1
• 负责人: Christopher Chiu
• 金额: $ 136.02万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902266%2F1
• 关键词: Cell; mediated; immunity; against; RSV

Influenza and respiratory syncytial virus (RSV) are among the most common causes of lung infection. They affect around 664 million people each year worldwide, causing an estimated 500,000 and 160,000 deaths respectively. Current influenza vaccines need to change every year to overcome rapid viral mutation, and there is still no RSV vaccine. Further research is therefore urgently needed. T cells are important in controlling viral infections, but there is not enough known about their role in humans with influenza and RSV. Furthermore, there is evidence that the T cell response to RSV is not fully protective, leading to multiple infections with the same strain of RSV in some people. This work will be carried out at the Centre for Respiratory Infection, Imperial College London within Professor Peter Openshaw‘s department. Healthy volunteers will be infected with either RSV or a weakened strain of influenza in order to examine the response of the T cells in their blood and lung secretions. By observing the changes in T cells following each infection, and comparing the responses to influenza and RSV, we aim to identify the essential components of an effective T cell response so that they can be used to create better vaccines.

流感和呼吸道合胞病毒（RSV）是肺部感染的最常见原因。它们每年影响全世界约6.64亿人，估计分别造成50万人和16万人死亡。目前的流感疫苗每年都需要改变，以克服病毒的快速突变，并且仍然没有RSV疫苗。因此，迫切需要进一步的研究。T细胞在控制病毒感染方面很重要，但对它们在流感和RSV患者中的作用还没有足够的了解。此外，有证据表明，T细胞对RSV的反应并不完全具有保护性，导致某些人多次感染同一株RSV。这项工作将在伦敦帝国理工学院呼吸道感染中心彼得·奥彭肖教授的部门内进行。健康志愿者将感染RSV或弱流感病毒株，以检查其血液和肺分泌物中T细胞的反应。通过观察每次感染后T细胞的变化，并比较对流感和RSV的反应，我们的目标是确定有效T细胞反应的基本组成部分，以便它们可以用于创建更好的疫苗。