CHEMISTRY OF NATURAL COMPOUNDS, AND SYNTHETIC ORGANIC CHEMISTRY

天然化合物化学和有机合成化学

• 批准号: 4689594
• 负责人: U WEISS
• 金额: --
• 依托单位: NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4689594
• 关键词: X ray crystallography; alkaloids; antineoplastic antibiotics; carbonyl compound; chemical models; chemical structure; chemical synthesis; circular dichroism; codeine; cooperative study; cyclopentane; diene; drug screening /evaluation; glutarates; infrared spectrometry; medicinal plants; morphine; nuclear magnetic resonance spectroscopy; opiate alkaloid; pigments; plant extracts; quinones; radiosensitizer; sesquiterpenes; stereochemistry; ultraviolet spectrometry; xanthines

The synthesis of di- and polycyclic systems composed of cyclopentane rings has been developed further, with particular emphasis upon elaboration of synthetic approaches to biologically active compounds of this type, and to deepened understanding of the mechanisms of the reactions utilized. Cooperation with the colleagues in India in the field of chemistry of morphine and codeine has been continued. Earlier studies on the chemistry of powerfully photosensitizing perylenequinones from certain molds has been continued. The complex stereochemistry of these mold metabolites presents unusual problems.

由环戊烷环组成的双环和多环体系的合成 得到了进一步发展，特别强调了 此类生物活性化合物的合成方法，以及 加深了对所用反应机制的理解。 与印度同行在化学领域的合作 吗啡和可待因已继续使用。 强光敏化学的早期研究 某些霉菌中的苝醌仍在继续。 综合体 这些霉菌代谢物的立体化学存在不寻常的问题。