Role of the endogenous signalling regulator Similar Expression to FGF (Sef) in growth factor signalling in prostate cancer

内源性信号调节因子与 FGF (Sef) 的相似表达在前列腺癌生长因子信号传导中的作用

• 批准号: G1001961/1
• 负责人: Satoshi Hori
• 金额: $ 16.98万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001961%2F1
• 关键词: Role; endogenous; signalling; regulator; Similar

Targeting growth factors in prostate cancer Prostate cancer is the commonest male malignancy in the UK (35000 new cases/year). Despite treatment including surgery, many patients will develop a lethal form of disease known as castration resistant prostate cancer. This process is driven in part by molecules called growth factors. We are investigating a gene called Sef which functions as a strong natural inhibitor of growth factors. Our aim is to test if increasing Sef in prostate tumours can enhance treatment designed to block growth factors. If successful, this will offer a new way to treat men with otherwise fatal prostate cancer.

针对前列腺癌中的生长因子前列腺癌是英国最常见的男性恶性肿瘤（每年 35000 例新病例）。尽管进行了包括手术在内的治疗，许多患者仍会患上一种致命的疾病，称为去势抵抗性前列腺癌。这个过程部分是由称为生长因子的分子驱动的。我们正在研究一种名为 Sef 的基因，它是生长因子的强天然抑制剂。我们的目的是测试增加前列腺肿瘤中的 Sef 是否可以增强旨在阻断生长因子的治疗。如果成功，这将为治疗患有致命前列腺癌的男性提供一种新方法。