A general conceptual and statistical framework to model non-linear and delayed exposure-response relationships and combi

用于建模非线性和延迟暴露-反应关系和组合的通用概念和统计框架

• 批准号: G1002296/1
• 负责人: Antonio Gasparrini
• 金额: $ 34.2万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002296%2F1
• 关键词: general; conceptual; statistical; framework; model

Scientific studies which assess the health effects of various risk factors usually depend on statistical models, used to quantify the relationship between the dose people are exposed to, and the health outcome. This relationship should concisely and reliably summarize the association, in order to correctly inform about the health consequences of specific risk factors. This association is usually estimated in multiple comparable studies, whose evidence needs then to be combined in order to improve the knowledge about related health risks.Researchers at the London School of Hygiene and Tropical Medicine, in collaboration with the MRC-Cambridge and the University of Southern California, have promoted a project to provide the statistical tools suitable to describe complex relationships and combine them across studies. These methodologies will be implemented in statistical software, freely available and usable by all the researchers working in different biomedical fields. The aim of the project is to improve the analytical method to study the association between risk factors and human health.

评估各种危险因素对健康影响的科学研究通常依赖于用于量化人们所受剂量与健康结果之间关系的统计模型。这种关系应简明而可靠地总结这种关联，以便正确地了解特定风险因素对健康的影响。这种关联通常是在多个可比研究中估计的，然后需要将这些研究的证据结合起来，以提高对相关健康风险的认识。伦敦卫生和热带医学学院的研究人员与mrc -剑桥和南加州大学合作，推动了一个项目，提供适合描述复杂关系的统计工具，并在研究中将它们结合起来。这些方法将在统计软件中实施，免费提供并可供不同生物医学领域的所有研究人员使用。该项目的目的是改进研究危险因素与人类健康之间关系的分析方法。