Auditory attention in the amnesia of Alzheimer's disease; and the response to a central cholinesterase inhibitor

阿尔茨海默病健忘症中的听觉注意力；

• 批准号: G1100423/1
• 负责人: Salwa Kamourieh
• 金额: $ 23.9万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100423%2F1
• 关键词: Auditory; attention; amnesia; Alzheimer; disease

Alzheimer‘s disease (AD), the most common form of dementia, is typically associated with poor memory for recent information and events. However, early in its course the disease affects other mental processes, and these contribute to the difficulties with memory. Thus, for example, remembering what one has been told when there are additional conversations in the background requires the ability to pay attention to one speaker and not be distracted by the others. Attention depends on a specialised right brain system, one whose function may be improved by the current drugs licensed to modify the symptoms of AD. My study plans to use imaging techniques to study the effects of AD on the functional and anatomical integrity of the attention system, and compare these results with those from age-matched normal subjects. I will then study the effects of a drug used to treat AD on the imaging measures, and relate these to any changes in psychological tests of memory and attention. Importantly, my study will separate natural variability in imaging measures from those due to the influence of the drug. This study will further our understanding of the effects of AD on higher brain functions and their treatment.

阿尔茨海默病（AD）是最常见的痴呆症，通常与对最近信息和事件的记忆力差有关。然而，在病程的早期，这种疾病会影响其他心理过程，这些都会导致记忆困难。因此，例如，当背景中有额外的对话时，记住一个人被告知的内容需要注意一个说话者的能力，而不是被其他人分散注意力。注意力依赖于一个专门的右脑系统，其功能可以通过目前被许可用于改善AD症状的药物来改善。我的研究计划使用成像技术来研究AD对注意系统的功能和解剖完整性的影响，并将这些结果与年龄匹配的正常受试者进行比较。然后，我将研究用于治疗AD的药物对成像测量的影响，并将这些与记忆和注意力的心理测试中的任何变化联系起来。重要的是，我的研究将把成像测量中的自然变异性与药物影响的自然变异性分开。这项研究将进一步加深我们对AD对高级脑功能的影响及其治疗的理解。