FLUORIDE MOUTHRINSING AND FLUORIDE TABLETS USED SEPARATELY AND IN COMBINATION

氟化物漱口剂和氟化物片剂单独和组合使用

• 批准号: 4692633
• 负责人: H S HOROWITZ
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692633
• 关键词: dental caries inhibitor; dosage forms; human subject; human therapy evaluation; ingested fluoride therapy; preschool child (1-5); preventive dentistry; topical fluoride therapy

Approximately 1700 kindergarten and first grade children were randomly assigned to one of the following groups: Group I - Rinses once every week in school with a 0.2% sodium fluoride solution. Group III - Ingests once a day in school a sodium fluoride tablet containing 1 mg of flouride. Group II - Carries out the regimens for both Group I and Group III. The method of assignment resulted in three comparable groups, each containing about 560 children. Participants carry out their assigned treatments in classrooms under the supervision of a teacher. Treatments will be administered for a minimum of eight and nine years for children initially in the fist grade and kindergarten, respectively. Baseline dental examinations were conducted in September 1981. The prescribed treatments were initiated shortly after the examinations were completed. In September 1984, the fourth school year of treatments began in the classrooms. First follow-up dental examinations were made in October 1983 of 1,154 participants who were then in grades 2 and 3. Supplies have been ordered, schedules arranged and local personnel identified for the start-up of the fifth school year of treatments in September 1985.

约 1700 名幼儿园和一年级儿童被随机抽取 分配给以下组之一： 第一组 - 在学校每周用 0.2% 氟化钠冲洗一次 解决方案。 第三组 - 在学校每天服用一次氟化钠片剂 含有1毫克氟化物。 第二组 - 执行第一组和第三组的治疗方案。 分配方法产生了三个可比较的组，每个组 包含约560名儿童。 参与者执行其分配的任务 在老师的监督下在教室进行治疗。 治疗方法 儿童将接受至少八至九岁的治疗 最初分别是一年级和幼儿园。 基线 1981 年 9 月进行了牙科检查。 检查完成后不久就开始治疗。 1984 年 9 月，第四学年的治疗开始于 教室。 1983 年 10 月进行了第一次后续牙科检查 共有 1,154 名二年级和三年级的参与者。用品已 启动命令、安排时间表并确定当地人员 1985 年 9 月第五学年的治疗。