Integrative genomic, epigenetic and functional studies in diabetic kidney disease

肾脏疾病是糖尿病的常见和破坏性并发症，是世界范围内的一个主要公共卫生问题。在决定谁会患上这种并发症方面发挥作用的遗传遗传因素开始被发现，这为了解糖尿病肾病的潜在生物学基础创造了机会，这将指导改进治疗和预防措施的发展。我们将结合和整合来自几种互补方法(遗传学、表观遗传学、基因表达分析和模型系统研究)的数据，以确定影响糖尿病肾脏疾病发展的基因和生物过程。

Kidney disease is a common and devastating complication of diabetes, and represents a major public health problem worldwide. The inherited, genetic factors that play a role in determining who will get this complication are beginning to be discovered, creating opportunities to understand the underlying biological basis of diabetic kidney disease, which will guide the development of improved treatments and preventive measures. We will combine and integrate data from several complementary approaches (genetics, epigenetics, gene expression analysis and studies in model systems) to identify genes and biological processes that influence the development of diabetic kidney disease.