INVOLVEMENT OF CALCIUM, FODRIN, AND GLUTAMATE IN SEIZURES

钙、卵黄蛋白和谷氨酸与癫痫发作有关

• 批准号: 4696978
• 负责人: S NADI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696978
• 关键词: calcium; cytoskeleton; epilepsy; glutamates; partial seizure

The work will involve the study of epileptic foci and the evaluation of the status of glutamate receptors, the cytoskeletal protein fodrin and the flux of calcium ions. The epileptic seizure has been demonstrated to occur as a result of a shift of external calcium ions to the interior of the cell. Since calcium ions are also known to activate calpain, which degrades fodrin, which is responsible for maintaining the integrity of the membrane. The question of interest in this study is to determine whether fodrin breakdown is directly linked to the spread of epileptic activity.

这项工作将涉及癫痫灶的研究和对 谷氨酸受体、细胞骨架蛋白及其通量的研究现状 钙离子。癫痫发作已被证明是一种 细胞外钙离子向细胞内部迁移的结果。 因为已知钙离子也能激活钙蛋白，而钙蛋白会降解 Fodrin，负责维护 薄膜。这项研究感兴趣的问题是确定 Fodrin的分解与癫痫活动的扩散直接相关。