DARE-FX: Delivering a federated network of TREs to enable safe analytics

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Trusted Research Environments (TREs) are secure locations in which data are placedfor researchers to analyse. They host administrative data, hospital data or any otherdata that must be securely isolated and only accessible for approved queries byapproved researchers. However, it is hard for a researcher to perform analysis acrossmultiple TREs, for example when data is to be analysed across geographical orgovernance boundaries, such as the devolved nature of healthcare in the UnitedKingdom. Yet this ability is urgently needed. Analysis across a federation of TREswould enable timely analysis of UK wide scattered data to answer urgent questions,as we needed in the COVID-19 pandemic.The technologies and standards we need to be able to do this are available now. Theydo not need to be invented. DARE-FX is assembling leading technology providers fromELIXIR-UK and HDR-UK, with three TRE providers and two leading analysis platformsto show through a real reference implementation how we can use secure ResearchObjects to move between TREs while still supporting the Five Safes principles thatgovern and protect patient data; all overseen by patient representatives.The impact will be a step change for how researchers can safely combine data frommany sources, and for how data providers from any sector can safely implement thisusing technology and standards we already have today.