Creating a West African BioResource for Nutritional Genetics and Epigenetics

为营养遗传学和表观遗传学创建西非生物资源

• 批准号: MC_PC_MR/R020183/1
• 负责人: Andrew Prentice
• 金额: $ 23.72万
• 依托单位: MRC Unit the Gambia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_MR%2FR020183%2F1
• 关键词: Creating; West; African; BioResource; Nutritional

The Nutrition Theme at MRC Unit The Gambia will partner with a broad team of collaborators in Bristol (Bristol University and MRC Integrative Epidemiology Unit) to create a new West African BioResource (WABR). The new bioresource will consist of rich nutritional cohorts, databases and the Keneba Biobank constructed over decades of research in the West Kiang area of rural Gambia. These will be made open access to worldwide collaborators to support novel research methods to better understand the complex relationships between diet, nutritional status and infectious and non-communicable diseases. The new methodologies will be strongly based on a genes-in-action (alternatively known as recall-by-genotype) paradigm that allows investigators to research the impact of genetic and epigenetic variants on health with highly efficient studies using small numbers of participants. Based upon the Bristol group's world-leading processes we will conduct a 'clone and adapt' exercise to bring the Gambian bioresource up to the same world standard. This process will be extended to the biobanks at MRCG Fajara and at our West African Global Health Alliance (WAGHA) partner institute IRESSEF in Dakar. We will also prepare a bioresource toolkit that can be accessed by other institutes with cohorts and biobanks in other LMICs.

冈比亚MRC单位的营养主题将与布里斯托尔(布里斯托尔大学和MRC综合流行病学单位)的广泛合作者团队合作，创建一个新的西非生物资源(WABR)。新的生物资源将包括丰富的营养队列、数据库和在冈比亚农村西江地区经过数十年研究建立的Keneba生物库。这些将向世界各地的合作者开放，以支持新的研究方法，以更好地了解饮食、营养状况与传染病和非传染性疾病之间的复杂关系。新的方法将在很大程度上基于基因作用(也称为按基因召回)范式，允许研究人员通过使用少量参与者的高效研究来研究遗传和表观遗传变异对健康的影响。基于布里斯托尔集团世界领先的工艺，我们将进行一项‘克隆和适应’工作，使冈比亚的生物资源达到同样的世界标准。这一进程将扩展到MRCG Fajara的生物库和我们在达喀尔的西非全球卫生联盟伙伴研究所IRESSEF。我们还将准备一个生物资源工具包，供其他拥有队列和其他LMIC生物库的机构使用。

项目成果

DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study.

• DOI: 10.1186/s13148-021-01213-3
• 发表时间: 2022-01-09
• 期刊: Clinical epigenetics
• 影响因子: 5.7
• 作者: Antoun E;Issarapu P;di Gravio C;Shrestha S;Betts M;Saffari A;Sahariah SA;Sankareswaran A;Arumalla M;Prentice AM;Fall CHD;Silver MJ;Chandak GR;Lillycrop KA;EMPHASIS study group
• 通讯作者: EMPHASIS study group

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

• DOI: 10.1038/s41467-018-03109-y
• 发表时间: 2018-02-19
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Corbin LJ;Tan VY;Hughes DA;Wade KH;Paul DS;Tansey KE;Butcher F;Dudbridge F;Howson JM;Jallow MW;John C;Kingston N;Lindgren CM;O'Donavan M;O'Rahilly S;Owen MJ;Palmer CNA;Pearson ER;Scott RA;van Heel DA;Whittaker J;Frayling T;Tobin MD;Wain LV;Smith GD;Evans DM;Karpe F;McCarthy MI;Danesh J;Franks PW;Timpson NJ
• 通讯作者: Timpson NJ

Thiamine deficiency in Gambian women of reproductive age.

• DOI: 10.1111/nyas.14695
• 发表时间: 2022-01
• 期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
• 影响因子: 5.2
• 作者: Bourassa, Megan W.;Gomes, Filomena;Jones, Kerry S.;Koulman, Albert;Prentice, Andrew M.;Cerami, Carla
• 通讯作者: Cerami, Carla

DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children.

• DOI: 10.1126/sciadv.abj1561
• 发表时间: 2021-11-05
• 期刊: Science advances
• 影响因子: 13.6
• 作者: Candler T;Kessler NJ;Gunasekara CJ;Ward KA;James P;Laritsky E;Baker MS;Dyer R;Elango R;Jeffries D;Waterland RA;Moore SE;Ludgate M;Prentice AM;Silver MJ
• 通讯作者: Silver MJ

Aflatoxin Exposure during Early Life Is Associated with Differential DNA Methylation in Two-Year-Old Gambian Children.

• DOI: 10.3390/ijms22168967
• 发表时间: 2021-08-20
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Ghantous A;Novoloaca A;Bouaoun L;Cuenin C;Cros MP;Xu Y;Hernandez-Vargas H;Darboe MK;Prentice AM;Moore SE;Gong YY;Herceg Z;Routledge MN
• 通讯作者: Routledge MN