Method - Design
方法-设计
基本信息
- 批准号:MC_UU_00004/09
- 负责人:
- 金额:$ 275.23万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Intramural
- 财政年份:2021
- 资助国家:英国
- 起止时间:2021 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Randomised trials are the best way to find out what treatments work, but they can be slow and expensive. We are inventing new and efficient ways to design randomised trials that can give clear answers, often answering multiple questions within the same trial. This work is supported by detailed statistical modelling to show how to analyse the new designs while strictly controlling the risk of wrongly concluding that a treatment is effective when in truth it isn’t. The new designs are implemented in our own trials, and this helps us to refine the designs and demonstrate their value for other trials.Our novel designs are for 1. trials to evaluate whether it is safe to shorten the duration of treatment or use a treatment with fewer side effects;2. trials to evaluate multiple treatments, where we can drop treatments that are found to be ineffective, adopt the use of treatments that are found to be effective, and start evaluating new promising treatments;3. trials that work even when the benefit of treatment is short-term or delayed; 4. trials where groups of patients are randomised rather than individual patients; 5. trials specifically designed to evaluate treatments tailored to specific types of patient; and6. trials comparing a number of treatments, where some patients cannot receive some of the treatments.The results of our work are that treatments can be evaluated faster, more effectively and more cost-effectively.
随机试验是发现治疗有效的最佳方法,但它们可能缓慢而昂贵。我们正在发明新的有效方法来设计随机试验,这些试验可以给出明确的答案,通常在同一试验中回答多个问题。这项工作得到了详细的统计建模的支持,以展示如何分析新的设计,同时严格控制错误地得出治疗有效的结论的风险,而实际上它不是。新的设计在我们自己的试验中实施,这有助于我们改进设计,并证明其对其他试验的价值。评估缩短治疗时间或使用副作用较少的治疗是否安全的试验;2.评估多种治疗方法的试验,我们可以放弃发现无效的治疗方法,采用发现有效的治疗方法,并开始评估新的有希望的治疗方法;3.即使在治疗的益处是短期或延迟的情况下也有效的试验; 4.随机分组患者而非单个患者的试验; 5.专门设计用于评估针对特定类型患者的治疗的试验;以及6.我们的工作成果是可以更快、更有效、更经济地评估治疗方法。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Multi-arm Multi-stage (MAMS) Platform Randomized Clinical Trials
多臂多阶段(MAMS)平台随机临床试验
- DOI:
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Choodari-Oskooei B
- 通讯作者:Choodari-Oskooei B
Starting a conversation about estimands with public partners involved in clinical trials: a co-developed tool.
- DOI:10.1186/s13063-023-07469-9
- 发表时间:2023-07-06
- 期刊:
- 影响因子:2.5
- 作者:
- 通讯作者:
Evaluating how clear the questions being investigated in randomised trials are: systematic review of estimands.
- DOI:10.1136/bmj-2022-070146
- 发表时间:2022-08-23
- 期刊:
- 影响因子:105.7
- 作者:Cro, Suzie;Kahan, Brennan C.;Rehal, Sunita;Ster, Anca Chis;Carpenter, James R.;White, Ian R.;Cornelius, Victoria
- 通讯作者:Cornelius, Victoria
Predicting prognosis for adults with depression using individual symptom data: a comparison of modelling approaches.
使用个体症状数据预测抑郁症的成年人的预后:建模方法的比较。
- DOI:10.1017/s0033291721001616
- 发表时间:2023-01
- 期刊:
- 影响因子:6.9
- 作者:Buckman, J. E. J.;Cohen, Z. D.;O'Driscoll, C.;Fried, E., I;Saunders, R.;Ambler, G.;DeRubeis, R. J.;Gilbody, S.;Hollon, S. D.;Kendrick, T.;Watkins, E.;Eley, T. C.;Peel, A. J.;Rayner, C.;Kessler, D.;Wiles, N.;Lewis, G.;Pilling, S.
- 通讯作者:Pilling, S.
Facilities for optimizing and designing multiarm multistage (MAMS) randomized controlled trials with binary outcomes
- DOI:10.1177/1536867x231196295
- 发表时间:2023-09-01
- 期刊:
- 影响因子:4.8
- 作者:Choodari-Oskooei,Babak;Bratton,Daniel J.;Parmar,Mahesh K. B.
- 通讯作者:Parmar,Mahesh K. B.
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Ian White其他文献
Acceptable risk of contact allergy in the general population assessed by CE–DUR – A method to detect and categorize contact allergy epidemics based on patient data
- DOI:
10.1016/j.yrtph.2009.04.001 - 发表时间:
2009-07-01 - 期刊:
- 影响因子:
- 作者:
Jacob Pontoppidan Thyssen;Torkil Menné;Axel Schnuch;Wolfgang Uter;Ian White;Jonathan M. White;Jeanne Duus Johansen - 通讯作者:
Jeanne Duus Johansen
Inadvertent epidural administration of potassium chloride
- DOI:
10.1007/bf03020353 - 发表时间:
1988-11-01 - 期刊:
- 影响因子:3.300
- 作者:
Michael J. Tessler;Ian White;MaryAnne Naugler-Colville;Diane R. Biehl - 通讯作者:
Diane R. Biehl
Background Little isknown about whatcharacteristics of teams, staff and patients are associatedwith a favourable outcome of severemental illnessmanaged byassertive outreach. Aims Toidentifypredictorsof voluntary and compulsory admissions in routine assertive outreach services in the UK. Method Nine
背景 对于团队、工作人员和患者的哪些特征与积极外展管理的严重精神疾病的良好结果相关,人们知之甚少。
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
S. Priebe;W. Fakhoury;Ian White;Joanna Watts;P. Bebbington;J. Billings;T. Burns;Sonia Johnson;M. Muijen - 通讯作者:
M. Muijen
Who wants to terminate the game? The role of vested interests and metaplayers in the ATOLLGAME experience
谁想终止游戏?
- DOI:
10.1177/1046878107300673 - 发表时间:
2007 - 期刊:
- 影响因子:2
- 作者:
A. Dray;P. Perez;Christophe Le Page;P. D'Aquino;Ian White - 通讯作者:
Ian White
Response to Limited surface impacts of the January 2021 sudden stratospheric warming
对 2021 年 1 月平流层突然变暖有限地表影响的响应
- DOI:
10.1038/s41467-023-38772-3 - 发表时间:
2023-06-07 - 期刊:
- 影响因子:15.700
- 作者:
Judah Cohen;Laurie Agel;Mathew Barlow;Chaim I. Garfinkel;Ian White - 通讯作者:
Ian White
Ian White的其他文献
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{{ truncateString('Ian White', 18)}}的其他基金
REU Site: New approaches to engineering cells, tissues, and organs
REU 网站:工程细胞、组织和器官的新方法
- 批准号:
1757745 - 财政年份:2018
- 资助金额:
$ 275.23万 - 项目类别:
Standard Grant
Multiple imputation by chained equations for data that are missing not at random: methods development for randomised trials and observational studies
通过链式方程对非随机丢失的数据进行多重插补:随机试验和观察性研究的方法开发
- 批准号:
MC_EX_MR/M025012/1 - 财政年份:2016
- 资助金额:
$ 275.23万 - 项目类别:
Research Grant
CAREER: Paper-based surface enhanced Raman spectroscopy (P-SERS) for biosensing using inkjet-fabricated devices
职业:使用喷墨制造设备进行生物传感的纸基表面增强拉曼光谱 (P-SERS)
- 批准号:
1149850 - 财政年份:2012
- 资助金额:
$ 275.23万 - 项目类别:
Standard Grant
SBIR Phase I: Extension of Multiphoton Polymerization fabrication technology to the fabrication of Retinal Image Management (RIM) elements
SBIR 第一阶段:将多光子聚合制造技术扩展到视网膜图像管理 (RIM) 元件的制造
- 批准号:
0638051 - 财政年份:2007
- 资助金额:
$ 275.23万 - 项目类别:
Standard Grant
SBIR Phase I: Spatially selective metallization of microfabricated 3D structures and lines using Multiphoton Polymerization (MPP) for optical, photonic and electrical micro-systems
SBIR 第一阶段:使用多光子聚合 (MPP) 对光学、光子和电气微系统进行微加工 3D 结构和线条的空间选择性金属化
- 批准号:
0638055 - 财政年份:2007
- 资助金额:
$ 275.23万 - 项目类别:
Standard Grant
SBIR Phase I: Simulation Model for Two-Photon Absorption Fabricated Microstructures
SBIR 第一阶段:双光子吸收制造微结构的仿真模型
- 批准号:
0512759 - 财政年份:2005
- 资助金额:
$ 275.23万 - 项目类别:
Standard Grant
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