REU Site: New approaches to engineering cells, tissues, and organs

REU 网站：工程细胞、组织和器官的新方法

• 批准号: 1757745
• 负责人: Ian White
• 金额: $ 35.48万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1757745&HistoricalAwards=false
• 关键词: REU; Site; New; approaches; engineering

The goal of this Research Experiences for Undergraduates (REU) Site is to advance the training and to increase the diversity of the next generation of researchers and regulatory engineers and scientists. Ten participants annually will pursue independent research to advance fundamental science in cellular and tissue engineering while developing new technologies, including 3D printing and miniaturized biological organ systems. Participants will also gain valuable training through workshops in the relevant technical skills, as well as lab notebook skills, technical writing and figure design, the U.S. Food and Drug Administration (FDA) approval process, and the responsible conduct of research. In addition, leveraging a partnership between the University of Maryland and the FDA undergraduate researchers will have the opportunity to contribute to the science of regulating the translatable outcomes of fundamental research in cell and tissue engineering. Thus, this REU site not only enriches future engineers and scientists, it also emphasizes the development of the next generation regulatory engineer and scientist. In this REU site, mentored undergraduate researchers will investigate innovative approaches to engineer cells, tissues, and organs. Projects include organ-on-a-chip (including blood-brain-barrier, gut, kidney, lymph node), cancer cell microenvironment on a chip, biomanufacturing-on-a-chip, and 3D-printed tissue engineering constructs. Investigations into each of these topics will add to the fundamental knowledge in cell and tissue engineering while advancing the engineering techniques of 3D printed biological systems and organ-on-a-chip systems. Furthermore, by inspecting fundamental bioengineering questions through the lens of the FDA, the investigations will enhance the field of regulatory science. Advances in molecular-, cellular-, and tissue-based therapies present significant challenges for regulation and commercialization; a well-trained workforce with perspectives on technology advances, ethical issues, and health safety will be critical to the proper translation of these technologies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该本科生研究体验 (REU) 网站的目标是推进培训并增加下一代研究人员、监管工程师和科学家的多样性。每年有 10 名参与者将进行独立研究，以推进细胞和组织工程的基础科学，同时开发新技术，包括 3D 打印和微型生物器官系统。 参与者还将通过研讨会获得有关相关技术技能、实验室笔记本技能、技术写作和图形设计、美国食品和药物管理局 (FDA) 审批流程以及负责任的研究行为等方面的宝贵培训。此外，利用马里兰大学和 FDA 本科研究人员之间的合作伙伴关系，将有机会为调节细胞和组织工程基础研究可转化成果的科学做出贡献。因此，这个REU站点不仅丰富了未来的工程师和科学家，还强调了下一代监管工程师和科学家的发展。 在这个 REU 网站中，受指导的本科生研究人员将研究改造细胞、组织和器官的创新方法。 项目包括芯片器官（包括血脑屏障、肠道、肾脏、淋巴结）、芯片癌细胞微环境、芯片生物制造和 3D 打印组织工程结构。 对每个主题的研究都将增加细胞和组织工程的基础知识，同时推进 3D 打印生物系统和芯片器官系统的工程技术。 此外，通过 FDA 的视角检查基本的生物工程问题，这些调查将加强监管科学领域的发展。基于分子、细胞和组织的疗法的进步给监管和商业化带来了重大挑战；一支训练有素、对技术进步、道德问题和健康安全有看法的员工队伍对于这些技术的正确转化至关重要。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。