Physical Activity Epidemiology

体力活动流行病学

• 批准号: MC_UU_00006/4
• 负责人: Soren Brage
• 金额: $ 432.46万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00006%2F4
• 关键词: Physical; Activity; Epidemiology

The overall aim of this programme is to understand the detailed relationships between physical activity and disease, particularly obesity and metabolic disorders. Further, we are also examining how the environment, early life factors such as birth weight, and genes affect the associations between physical activity with obesity and metabolic disorders. We have lead the development and evaluation of an objective method based on the combined measurement of heart rate and body movement for measuring physical activity precisely in free living individuals. This technique is now implemented in our epidemiological studies and in collaboration with researchers in UK and abroad. We will use this method in future studies. We seek to understand population levels of physical activity and how activity levels might change by time and between sub-groups of the population. We have shown that physical activity is positively associated with metabolic disorders in both children and adults and this association is independent of aerobic fitness. This has important public health implications as it may be more feasible to encourage the population to increase their levels of activity rather than improving aerobic fitness which is likely to include more vigorous exercise. We will seek to further examine the importance of physical activity in the causation of disease and how these associations differ between sub groups of the population. For example, we will include precise measurements of physical activity and body composition from early age in various birth cohorts. Finally, we will examine the heritability of activity in twin studies and the genetic determinants of activity in large scale observational studies.

该计划的总体目标是了解体力活动与疾病之间的详细关系，特别是肥胖和代谢紊乱。此外，我们还在研究环境、出生体重等早期生活因素和基因如何影响体力活动与肥胖和代谢紊乱之间的关联。我们主导开发和评估了一种基于心率和身体运动联合测量的客观方法，用于精确测量自由生活个体的身体活动。该技术现已在我们的流行病学研究中实施，并与英国和国外的研究人员合作。我们将在以后的研究中使用这种方法。我们试图了解人群的体力活动水平以及活动水平如何随时间以及人口亚组之间的变化。我们已经证明，体力活动与儿童和成人的代谢紊乱呈正相关，并且这种关联与有氧健身无关。这具有重要的公共卫生影响，因为鼓励人们增加活动水平可能比改善有氧健身更可行，因为有氧健身可能包括更剧烈的运动。我们将寻求进一步研究体力活动在疾病病因中的重要性，以及这些关联在不同人群之间有何不同。例如，我们将包括对不同出生群体从小的身体活动和身体成分的精确测量。最后，我们将检查双胞胎研究中活动的遗传性以及大规模观察研究中活动的遗传决定因素。

项目成果

The association between sleep duration and detailed measures of obesity: A cross sectional analysis in the ADDITION-PRO study.

• DOI: 10.1002/osp4.640
• 发表时间: 2023-06
• 期刊: OBESITY SCIENCE & PRACTICE
• 影响因子: 2.2
• 作者: Andersen, Mie M.;Laurberg, Tinne;Bjerregaard, Anne-Louise;Sandbaek, Annelli;Brage, Soren;Vistisen, Dorte;Quist, Jonas S.;Bruun, Jens M.;Witte, Daniel R.
• 通讯作者: Witte, Daniel R.

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.

通过生成深度学习模型发现 2 型糖尿病的药物组学关联。

• DOI: 10.17863/cam.92630
• 发表时间: 2023
• 作者: Allesøe R

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

• DOI: 10.1101/2020.02.10.20021147
• 发表时间: 2020-02
• 期刊: medRxiv
• 作者: N. Atabaki-Pasdar;M. Ohlsson;A. Viñuela;F. Frau;H. Pomares-Millan;Mark Haid;A. Jones;Elizabeth Louise Thomas;R. Koivula;A. Kurbasic;Pascal M. Mutie;H. Fitipaldi;Juan Fernandez;A. Dawed;G. Giordano;I. Forgie;T. Mcdonald;F. Rutters;H. Cederberg;E. Chabanova;M. Dale;Federico De Masi;C. Thomas;K. Allin;T. Hansen;Alison J. Heggie;Mun-Gwan Hong;P. Elders;G. Kennedy;T. Kokkola;H. Pedersen;A. Mahajan;D. McEvoy;F. Pattou;V. Raverdy;Ragna S. Häussler;Sapna Sharma;H. Thomsen;J. Vangipurapu;H. Vestergaard;L. Hart;J. Adamski;P. Musholt;S. Brage;S. Brunak;E. Dermitzakis;G. Frost;T. Hansen;M. Laakso;O. Pedersen;M. Ridderstråle;H. Ruetten;A. Hattersley;M. Walker;J. Beulens;A. Mari;J. Schwenk;Ramneek Gupta;M. McCarthy;E. Pearson;Jimmy D Bell;I. Pávó;P. Franks

Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studies.

儿童和青少年的出生体重、心脏代谢危险因素以及体力活动的影响调整：来自 12 项国际研究的汇总数据。

• DOI: 10.17863/cam.51708
• 发表时间: 2020
• 作者: Bernhardsen G

The association between sleep duration and detailed measures of obesity: A cross sectional analysis in the ADDITION-PRO study

睡眠持续时间与肥胖详细测量之间的关联：ADDITION-PRO 研究中的横断面分析

• DOI: 10.17863/cam.88878
• 发表时间: 2022
• 作者: Andersen M