Physical activity epidemiology

身体活动流行病学

• 批准号: MC_UU_12015/3
• 负责人: Soren Brage
• 金额: $ 369.77万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12015%2F3
• 关键词: Physical; activity; epidemiology

The overall aim of this programme is to understand the detailed relationships between physical activity and disease, particularly obesity and metabolic disorders. Further, we are also examining how the environment, early life factors such as birth weight, and genes affect the associations between physical activity with obesity and metabolic disorders. We have lead the development and evaluation of an objective method based on the combined measurement of heart rate and body movement for measuring physical activity precisely in free living individuals. This technique is now implemented in our epidemiological studies and in collaboration with researchers in UK and abroad. We will use this method in future studies. We seek to understand population levels of physical activity and how activity levels might change by time and between sub-groups of the population. We have shown that physical activity is positively associated with metabolic disorders in both children and adults and this association is independent of aerobic fitness. This has important public health implications as it may be more feasible to encourage the population to increase their levels of activity rather than improving aerobic fitness which is likely to include more vigorous exercise. We will seek to further examine the importance of physical activity in the causation of disease and how these associations differ between sub groups of the population. For example, we will include precise measurements of physical activity and body composition from early age in various birth cohorts. Finally, we will examine the heritability of activity in twin studies and the genetic determinants of activity in large scale observational studies.

该方案的总体目标是了解体育活动与疾病，特别是肥胖和代谢紊乱之间的详细关系。此外，我们还在研究环境、早期生活因素（如出生体重）和基因如何影响体育活动与肥胖和代谢紊乱之间的联系。我们领导开发和评估了一种基于心率和身体运动结合测量的客观方法，用于精确测量自由生活个体的身体活动。这项技术现在在我们的流行病学研究中实施，并与英国和国外的研究人员合作。我们将在以后的研究中使用这种方法。我们试图了解人口的身体活动水平，以及活动水平如何随着时间和人口子群体之间的变化而变化。我们已经证明，体育活动与儿童和成人的代谢紊乱呈正相关，这种关联与有氧健身无关。这对公共健康有重要的影响，因为鼓励人们增加活动水平可能比改善有氧健身更可行，有氧健身可能包括更剧烈的运动。我们将进一步研究体育活动在疾病成因中的重要性，以及这些关联在人群亚组之间的差异。例如，我们将包括对不同出生队列的早期身体活动和身体成分的精确测量。最后，我们将在双胞胎研究中检查活动的遗传性，并在大规模观察研究中检查活动的遗传决定因素。

项目成果

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.

• DOI: 10.1371/journal.pgen.1003607
• 发表时间: 2013
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Ahmad S;Rukh G;Varga TV;Ali A;Kurbasic A;Shungin D;Ericson U;Koivula RW;Chu AY;Rose LM;Ganna A;Qi Q;Stančáková A;Sandholt CH;Elks CE;Curhan G;Jensen MK;Tamimi RM;Allin KH;Jørgensen T;Brage S;Langenberg C;Aadahl M;Grarup N;Linneberg A;Paré G;InterAct Consortium;DIRECT Consortium;Magnusson PK;Pedersen NL;Boehnke M;Hamsten A;Mohlke KL;Pasquale LT;Pedersen O;Scott RA;Ridker PM;Ingelsson E;Laakso M;Hansen T;Qi L;Wareham NJ;Chasman DI;Hallmans G;Hu FB;Renström F;Orho-Melander M;Franks PW
• 通讯作者: Franks PW

Preventing childhood obesity, phase II feasibility study focusing on South Asians: BEACHeS.

• DOI: 10.1136/bmjopen-2013-004579
• 发表时间: 2014-04-10
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Adab P;Pallan MJ;Cade J;Ekelund U;Barrett T;Daley A;Deeks J;Duda J;Gill P;Parry J;Bhopal R;Cheng KK
• 通讯作者: Cheng KK

Evaluation of reliability and validity of the General Practice Physical Activity Questionnaire (GPPAQ) in 60-74 year old primary care patients.

• DOI: 10.1186/s12875-015-0324-8
• 发表时间: 2015-09-02
• 期刊: BMC family practice
• 影响因子: 2.9
• 作者: Ahmad S;Harris T;Limb E;Kerry S;Victor C;Ekelund U;Iliffe S;Whincup P;Beighton C;Ussher M;Cook DG
• 通讯作者: Cook DG

Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study).

• DOI: 10.1136/bmj.k211
• 发表时间: 2018-02-07
• 期刊: BMJ (Clinical research ed.)
• 作者: Adab P;Pallan MJ;Lancashire ER;Hemming K;Frew E;Barrett T;Bhopal R;Cade JE;Canaway A;Clarke JL;Daley A;Deeks JJ;Duda JL;Ekelund U;Gill P;Griffin T;McGee E;Hurley K;Martin J;Parry J;Passmore S;Cheng KK
• 通讯作者: Cheng KK

A cluster-randomised controlled trial to assess the effectiveness and cost-effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6-7 year old children: the WAVES study protocol.

• DOI: 10.1186/s12889-015-1800-8
• 发表时间: 2015-05-13
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Adab P;Pallan MJ;Lancashire ER;Hemming K;Frew E;Griffin T;Barrett T;Bhopal R;Cade JE;Daley A;Deeks J;Duda J;Ekelund U;Gill P;McGee E;Parry J;Passmore S;Cheng KK
• 通讯作者: Cheng KK