The Epidemiology of Physical Activity and Lung Cancer

描述（由申请人提供）：此K奖提案包括 培训和研究经验，旨在让博士Rundle发展成为 一个独立的研究人员，专注于体育活动和癌症 流行病学培训部分包括指导工作， 活动和生活方式危险因素流行病学，肺癌流行病学， 肺癌的临床方面，以及生物标志物作为中间体的用途 端点。此外，该计划还包括生物统计学课程， 参加系列研讨会和会议，以及参加培训旅行 在其他机构做身体活动研究。 拟议的研究包括一项病例对照研究， 无论体力活动是否对肺癌有保护作用， 使用生物标志物作为中间终点的研究， 身体活动的作用机制。病例对照研究 将跟进队列和病例对照研究，这些研究表明， 运动对肺癌发展的影响， 更深入的身体活动和吸烟习惯的终身测量。 此外，这项研究将是第一个控制饮食作为一个潜在的 混淆因素。特别令人感兴趣的是， 戒烟是否有保护作用。生物标志物 这项研究响应了生物标志物研究的呼吁，生物标志物研究可以帮助阐明 身体活动的保护机制。这些研究可以提供 生物学支持观察到的与癌症的关联，并将有助于 确定所需运动的类型、频率和持续时间的信息 最大限度的保护。这项研究将确定体力活动是否 与谷胱甘肽和细胞外 谷胱甘肽过氧化物酶，以及这些标记物是否反过来与 降低PAH-DNA加合物和氧化损伤水平。这两个项目都 旨在开发新的肺癌预防计划， 补充目前的吸烟预防和戒烟计划。

DESCRIPTION (provided by applicant): This K award proposal encompasses training and research experiences designed to allow Dr. Rundle to develop into an independent researcher focusing on physical activity, and cancer epidemiology. The training component includes mentored work in physical activity and lifestyle risk factor epidemiology, lung cancer epidemiology, clinical aspects of lung cancer, and the use of biomarkers as intermediate endpoints. In addition, the plan includes biostatistics coursework, participation in seminar series and conferences, and trips to receive training at other institutions doing physical activity research. The proposed research includes a case-control study that will investigate whether physical activity, is protective against lung cancer, and a cross-sectional study that uses biomarkers as intermediate endpoints to investigate the mechanisms by which physical activity may act. The case-control study will follow up on cohort and case-control studies that have shown a protective effect of physical activity on lung cancer development and has the strength of more in depth life-time measures of physical activity and smoking habits. Furthermore, the study will be the first to control for diet as a potential confounder. Of particular interest is the affect of physical activity after smoking cessation and whether this has a protective effect. The biomarker study responds to calls for biomarker studies that can help to elucidate the protective mechanisms of physical activity. Such studies may provide biological support for observed associations with cancer, and will contribute information to determine the type, frequency, and duration of exercise needed for maximum protection. The study will determine whether physical activity is associated with increased levels of glutathione and extracellular glutathione peroxidase, and whether in turn these markers are associated with lower levels of PAH-DNA adducts and oxidative damage. Both projects are directed at the development of new lung cancer prevention programs that can supplement current smoking prevention and cessation programs.