The Epidemiology of Physical Activity and Lung Cancer

体力活动与肺癌的流行病学

• 批准号: 7058836
• 负责人: Andrew G Rundle
• 金额: $ 13.45万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-25 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058836
• 关键词: adult human (21+); antioxidants; bioenergetics; biomarker; body physical activity; cancer risk; case history; clinical research; diet; exercise; glutathione; glutathione peroxidase; human subject; lifestyle; lung neoplasms; neoplasm /cancer epidemiology; nutrition aspect of cancer; oxidative stress; postdoctoral investigator; questionnaires; smoking; smoking cessation; tobacco abuse

DESCRIPTION (provided by applicant): This K award proposal encompasses training and research experiences designed to allow Dr. Rundle to develop into an independent researcher focusing on physical activity, and cancer epidemiology. The training component includes mentored work in physical activity and lifestyle risk factor epidemiology, lung cancer epidemiology, clinical aspects of lung cancer, and the use of biomarkers as intermediate endpoints. In addition, the plan includes biostatistics coursework, participation in seminar series and conferences, and trips to receive training at other institutions doing physical activity research. The proposed research includes a case-control study that will investigate whether physical activity, is protective against lung cancer, and a cross-sectional study that uses biomarkers as intermediate endpoints to investigate the mechanisms by which physical activity may act. The case-control study will follow up on cohort and case-control studies that have shown a protective effect of physical activity on lung cancer development and has the strength of more in depth life-time measures of physical activity and smoking habits. Furthermore, the study will be the first to control for diet as a potential confounder. Of particular interest is the affect of physical activity after smoking cessation and whether this has a protective effect. The biomarker study responds to calls for biomarker studies that can help to elucidate the protective mechanisms of physical activity. Such studies may provide biological support for observed associations with cancer, and will contribute information to determine the type, frequency, and duration of exercise needed for maximum protection. The study will determine whether physical activity is associated with increased levels of glutathione and extracellular glutathione peroxidase, and whether in turn these markers are associated with lower levels of PAH-DNA adducts and oxidative damage. Both projects are directed at the development of new lung cancer prevention programs that can supplement current smoking prevention and cessation programs.

描述(由申请者提供)：本K奖励方案包括 培训和研究经验，旨在使Rundle博士发展成为 一位专注于体育运动和癌症的独立研究人员 流行病学。培训部分包括体能方面的指导工作 活动和生活方式危险因素流行病学、肺癌流行病学、 肺癌的临床方面，以及生物标志物作为中间体的使用 终端。此外，该计划还包括生物统计学课程， 参加系列研讨会和会议，以及前往接受培训 在其他机构做体力活动研究。 拟议的研究包括一项病例对照研究，该研究将调查 体力活动，是否对肺癌有保护作用，以及横截面 使用生物标记物作为中间终点的研究 体力活动的作用机制。病例对照研究 将跟进队列和病例对照研究，这些研究表明 体力活动对肺癌发生和发展的影响 更深入地衡量终身体育活动和吸烟习惯。 此外，这项研究将第一次将控制饮食作为一种潜在的 混血儿。特别令人感兴趣的是体力活动对身体的影响 戒烟以及这是否有保护作用。生物标记物 这项研究响应了对生物标记物研究的呼吁，这有助于阐明 体力活动的保护机制。这类研究可能会提供 为观察到的与癌症相关的生物支持，并将做出贡献 确定所需运动的类型、频率和持续时间的信息 以获得最大限度的保护。这项研究将确定体力活动是否 与谷胱甘肽和细胞外激素水平的升高有关 谷胱甘肽过氧化物酶，以及这些标志物是否反过来与 较低水平的多环芳烃-DNA加合物和氧化损伤。两个项目都是 旨在开发新的肺癌预防计划，这些计划可以 补充目前的吸烟预防和戒烟计划。

项目成果

Measures of genotype versus gene products: promise and pitfalls in cancer prevention.

基因型与基因产物的测量：癌症预防的希望和陷阱。

• DOI: 10.1093/carcin/bgg104
• 发表时间: 2003
• 期刊: Carcinogenesis.
• 作者: Ahsan,Habibul;Rundle,AndrewG
• 通讯作者: Rundle,AndrewG

Molecular epidemiology of physical activity and cancer.

体力活动与癌症的分子流行病学。

• 发表时间: 2005
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
• 作者: Rundle,Andrew

Issues in the epidemiological analysis and interpretation of intermediate biomarkers.

流行病学分析和中间生物标志物解释的问题。

• 发表时间: 2003
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Rundle,Andrew;Schwartz,Sharon
• 通讯作者: Schwartz,Sharon

Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.

• DOI: 10.3109/13547500903186452
• 发表时间: 2010-02
• 期刊: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
• 作者: Rundle A;Richie J;Steindorf K;Peluso M;Overvad K;Raaschou-Nielsen O;Clavel-Chapelon F;Linseisen JP;Boeing H;Trichopoulou A;Palli D;Krogh V;Tumino R;Panico S;Bueno-De-Mesquita HB;Peeters PH;Lund E;Gonzalez CA;Martinez C;Dorronsoro M;Barricarte A;Tormo MJ;Quiros J;Agudo A;Berglund G;Jarvholm B;Bingham S;Key TJ;Gormally E;Saracci R;Kaaks R;Riboli E;Vineis P
• 通讯作者: Vineis P

The interaction between alcohol consumption and GSTM1 genotype on polycyclic aromatic hydrocarbon-DNA adduct levels in breast tissue.

饮酒与 GSTM1 基因型之间的相互作用对乳腺组织中多环芳烃-DNA 加合物水平的影响。

• 发表时间: 2003
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Rundle,Andrew;Tang,Deliang;Mooney,LaVerne;Grumet,Surah;Perera,Frederica
• 通讯作者: Perera,Frederica