The Epidemiology of Physical Activity and Lung Cancer
The Epidemiology of Physical Activity and Lung Cancer
批准号:
7058836
负责人:
Andrew G Rundle
金额:
$13.45万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-06-25 至 2007-08-31
关键词:
adult human (21+)antioxidantsbioenergeticsbiomarkerbody physical activitycancer riskcase historyclinical researchdietexerciseglutathioneglutathione peroxidasehuman subjectlifestylelung neoplasmsneoplasm /cancer epidemiologynutrition aspect of canceroxidative stresspostdoctoral investigatorquestionnairessmokingsmoking cessationtobacco abuse
中文摘要
描述(由申请人提供):本K奖提案包括
英文摘要
DESCRIPTION (provided by applicant): This K award proposal encompasses
training and research experiences designed to allow Dr. Rundle to develop into
an independent researcher focusing on physical activity, and cancer
epidemiology. The training component includes mentored work in physical
activity and lifestyle risk factor epidemiology, lung cancer epidemiology,
clinical aspects of lung cancer, and the use of biomarkers as intermediate
endpoints. In addition, the plan includes biostatistics coursework,
participation in seminar series and conferences, and trips to receive training
at other institutions doing physical activity research.
The proposed research includes a case-control study that will investigate
whether physical activity, is protective against lung cancer, and a cross-sectional
study that uses biomarkers as intermediate endpoints to investigate
the mechanisms by which physical activity may act. The case-control study
will follow up on cohort and case-control studies that have shown a protective
effect of physical activity on lung cancer development and has the strength of
more in depth life-time measures of physical activity and smoking habits.
Furthermore, the study will be the first to control for diet as a potential
confounder. Of particular interest is the affect of physical activity after
smoking cessation and whether this has a protective effect. The biomarker
study responds to calls for biomarker studies that can help to elucidate the
protective mechanisms of physical activity. Such studies may provide
biological support for observed associations with cancer, and will contribute
information to determine the type, frequency, and duration of exercise needed
for maximum protection. The study will determine whether physical activity
is associated with increased levels of glutathione and extracellular
glutathione peroxidase, and whether in turn these markers are associated with
lower levels of PAH-DNA adducts and oxidative damage. Both projects are
directed at the development of new lung cancer prevention programs that can
supplement current smoking prevention and cessation programs.
期刊论文(7)
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Measures of genotype versus gene products: promise and pitfalls in cancer prevention.
基因型与基因产物的测量:癌症预防的希望和陷阱。
DOI:
10.1093/carcin/bgg104
发表时间:
2003
期刊:
Carcinogenesis.
影响因子:
--
作者:
[Ahsan,Habibul, Rundle,AndrewG]
通讯作者:
Rundle,AndrewG
Molecular epidemiology of physical activity and cancer.
体力活动与癌症的分子流行病学。
DOI:
--
发表时间:
2005
期刊:
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子:
--
作者:
[Rundle,Andrew]
通讯作者:
Rundle,Andrew
Issues in the epidemiological analysis and interpretation of intermediate biomarkers.
流行病学分析和中间生物标志物解释的问题。
DOI:
--
发表时间:
2003
期刊:
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子:
--
作者:
[Rundle,Andrew, Schwartz,Sharon]
通讯作者:
Schwartz,Sharon
DOI:
10.3109/13547500903186452
发表时间:
2010-02
期刊:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
影响因子:
--
作者:
[Rundle A, Richie J, Steindorf K, Peluso M, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen JP, Boeing H, Trichopoulou A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Tormo MJ, Quiros J, Agudo A, Berglund G, Jarvholm B, Bingham S, Key TJ, Gormally E, Saracci R, Kaaks R, Riboli E, Vineis P]
通讯作者:
Vineis P
The interaction between alcohol consumption and GSTM1 genotype on polycyclic aromatic hydrocarbon-DNA adduct levels in breast tissue.
饮酒与 GSTM1 基因型之间的相互作用对乳腺组织中多环芳烃-DNA 加合物水平的影响。
DOI:
--
发表时间:
2003
期刊:
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子:
--
作者:
[Rundle,Andrew, Tang,Deliang, Mooney,LaVerne, Grumet,Surah, Perera,Frederica]
通讯作者:
Perera,Frederica
Identifying alcohol-related and built environment factors that can be modified to prevent pedestrian road traffic death
-
批准号:10428536
-
项目类别:
-
资助金额:$65.76万
-
财政年份:2021
-
负责人:Andrew G Rundle
-
依托单位:
Identifying alcohol-related and built environment factors that can be modified to prevent pedestrian road traffic death
-
批准号:10207843
-
项目类别:
-
资助金额:$71.95万
-
财政年份:2021
-
负责人:Andrew G Rundle
-
依托单位:
Identifying alcohol-related and built environment factors that can be modified to prevent pedestrian road traffic death
-
批准号:10602550
-
项目类别:
-
资助金额:$65.96万
-
财政年份:2021
-
负责人:Andrew G Rundle
-
依托单位:
Project 1: Endocrine Disruptors & Obesity Among Inner-City Children
-
批准号:8322716
-
项目类别:
-
资助金额:$19.43万
-
财政年份:2011
-
负责人:Andrew G Rundle
-
依托单位:
Using Google Streetview to Measure Neighborhood Characteristics
-
批准号:7771224
-
项目类别:
-
资助金额:$24.79万
-
财政年份:2010
-
负责人:Andrew G Rundle
-
依托单位:
Neighborhood Environments and Disparities in Obesity Rates in New York City
-
批准号:8017874
-
项目类别:
-
资助金额:$4.36万
-
财政年份:2010
-
负责人:Andrew G Rundle
-
依托单位:
Using Google Streetview to Measure Neighborhood Characteristics
-
批准号:8112009
-
项目类别:
-
资助金额:$20.06万
-
财政年份:2010
-
负责人:Andrew G Rundle
-
依托单位:
Neighborhood Environments and Disparities in Obesity Rates in New York City
-
批准号:7812116
-
项目类别:
-
资助金额:$55.51万
-
财政年份:2009
-
负责人:Andrew G Rundle
-
依托单位:
Neighborhood Environments and Disparities in Obesity Rates in New York City
-
批准号:7652561
-
项目类别:
-
资助金额:$56.53万
-
财政年份:2009
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7452704
-
项目类别:
-
资助金额:$0.58万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7278801
-
项目类别:
-
资助金额:$48.28万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7120086
-
项目类别:
-
资助金额:$42.46万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7679784
-
项目类别:
-
资助金额:$13.74万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7001854
-
项目类别:
-
资助金额:$43.38万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7845341
-
项目类别:
-
资助金额:$3.48万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
Obesity, Physical Activity and Built Space in New York City
-
批准号:7474518
-
项目类别:
-
资助金额:$40.95万
-
财政年份:2005
-
负责人:Andrew G Rundle
-
依托单位:
The Epidemiology of Physical Activity and Lung Cancer
-
批准号:6888905
-
项目类别:
-
资助金额:$13.45万
-
财政年份:2002
-
负责人:Andrew G Rundle
-
依托单位:
The Epidemiology of Physical Activity and Lung Cancer
-
批准号:6603239
-
项目类别:
-
资助金额:$13.45万
-
财政年份:2002
-
负责人:Andrew G Rundle
-
依托单位:
The Epidemiology of Physical Activity and Lung Cancer
-
批准号:6751651
-
项目类别:
-
资助金额:$13.45万
-
财政年份:2002
-
负责人:Andrew G Rundle
-
依托单位:
The Epidemiology of Physical Activity and Lung Cancer
-
批准号:6472366
-
项目类别:
-
资助金额:$13.45万
-
财政年份:2002
-
负责人:Andrew G Rundle
-
依托单位:
海外基金