Diet, physical activity and cardiometabolic health in Malaysian adolescents: from epidemiology to intervention

马来西亚青少年的饮食、身体活动和心脏代谢健康：从流行病学到干预

• 批准号: MR/P013821/1
• 负责人: Laura Johnson
• 金额: $ 25.67万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP013821%2F1
• 关键词: Diet; physical; activity; cardiometabolic; health

In Malaysia the prevalence of obesity among adolescents is increasing and non-communicable diseases, like type 2 diabetes and cardiovascular disease, account for two out of three deaths. While research in European and US-based populations has found that particular lifestyle factors might cause adolescents to be fatter and less fit we do not have a complete picture of what causes these problems in Malaysia. In this study we are going to look at how different lifestyle factors, like foods eaten, timing or frequency of eating, physical activity, sedentary behaviours and their timing or location, combine together to create an overall behavioural pattern score that indicates whether adolescents have good health. We've previously found that a combination of factors is more important for health compared with single factors alone. Initial analysis of health outcomes will focus on obesity, blood pressure, and how much LDL cholesterol, fats and glucose are in blood samples. We also plan to use a new, reproducible laboratory technique, known as metabolomics, to measure 233 different components of blood that indicate a range of metabolic processes. This will help us find out in much more detail than ever before how behaviour leads to better cardiovascular health via metabolic pathways. When we know more about the pathway that leads from lifestyle to disease we will be better able to predict who will stay healthy and who will not. In this study, one of our aims is to find the main behaviours related to keeping a healthy metabolism and reducing the risk of cardiovascular disease in the future. We'll then work out how these behaviours can changed by an intervention.This research is possible because of a large study of over 1361 adolescents, called MyHeARTs. The aim of MyHeARTs was to identify which factors best predict health to enable the early detection and prevention of type 2 diabetes and cardiovascular disease. MyHeARTs started in 2012, collecting information on the behaviour and health of 1361 adolescents from 15 urban and rural schools in 3 regions of Malaysia and has just completed a third follow-up in 2016. The participants have provided detailed reports of their diet, activity, and other health behaviours as well as measurements of body composition, physical fitness and blood samples at age 13, 15 and 17, which we will use for this study. We are interested to see whether combinations of lifestyle behaviours can accurately predict changes in the blood chemical profile of participants as they progress through adolescence before they develop clear symptoms of cardiovascular disease or diabetes.Finally, within this project we lay the foundations for improving adolescents' metabolic health. We will talk to adolescents and school staff about how they could adopt the behaviours we found were important for health in MyHeART. We will then use their views paired with known methods of behaviour change to encourage a healthy lifestyle and prevent disease that will work in countries, like Malaysia, where resources are limited.

在马来西亚，青少年肥胖率正在上升，2型糖尿病和心血管疾病等非传染性疾病占死亡人数的三分之二。虽然对欧洲和美国人群的研究发现，特定的生活方式因素可能会导致青少年变得更胖、更不健康，但我们并不完全清楚是什么导致了马来西亚的这些问题。在这项研究中，我们将研究不同的生活方式因素，如饮食、进食时间或频率、体育活动、久坐行为及其时间或地点，如何结合在一起，创造出表明青少年是否健康的总体行为模式得分。我们之前已经发现，与单一因素相比，综合因素对健康更重要。对健康结果的初步分析将集中在肥胖、血压以及血液样本中有多少低密度脂蛋白、脂肪和葡萄糖。我们还计划使用一种新的、可重复使用的实验室技术，称为代谢组学，来测量233种不同的血液成分，这些成分表明了一系列代谢过程。这将帮助我们比以往任何时候都更详细地了解行为如何通过代谢途径导致更好的心血管健康。当我们更多地了解从生活方式到疾病的途径时，我们就能更好地预测谁会保持健康，谁不会。在这项研究中，我们的目标之一是找到与保持健康新陈代谢和降低未来心血管疾病风险相关的主要行为。然后，我们将研究如何通过干预来改变这些行为。这项研究之所以可能，是因为一项名为MyHeART的针对1361名青少年的大型研究。MyHeARTS的目的是确定哪些因素最能预测健康，从而能够及早发现和预防2型糖尿病和心血管疾病。MyHeARTS始于2012年，从马来西亚3个地区的15所城乡学校收集了1361名青少年的行为和健康信息，2016年刚刚完成了第三次跟进。参与者提供了关于他们的饮食、活动和其他健康行为的详细报告，以及13岁、15岁和17岁时的身体成分、身体健康和血液样本的测量，我们将在本研究中使用这些数据。我们感兴趣的是，在参与者出现明显的心血管疾病或糖尿病症状之前，生活方式行为的组合是否能够准确预测参与者在青春期过程中血液化学特征的变化。最后，在这个项目中，我们为改善青少年的代谢健康奠定了基础。我们将与青少年和学校教职员工讨论他们如何采取我们认为对我的心脏健康很重要的行为。然后，我们将把他们的观点与已知的行为改变方法结合起来，以鼓励健康的生活方式和预防疾病，这将在资源有限的马来西亚等国家奏效。

项目成果

Social Gradients and Physical Activity Trends in an Obesogenic Dietary Pattern: Cross-Sectional Analysis of the UK National Diet and Nutrition Survey 2008-2014.

• DOI: 10.3390/nu10040388
• 发表时间: 2018-03-22
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Johnson L;Toumpakari Z;Papadaki A
• 通讯作者: Papadaki A

Facilitators and Barriers to Implementing Healthy School Canteen Intervention among Malaysian Adolescents: A Qualitative Study.

• DOI: 10.3390/nu13093078
• 发表时间: 2021-09-01
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Azizan NA;Papadaki A;Su TT;Jalaludin MY;Mohammadi S;Dahlui M;Nahar Azmi Mohamed M;Majid HA
• 通讯作者: Majid HA

Perceptions of eating practices and physical activity among Malaysian adolescents in secondary schools: a qualitative study with multi-stakeholders

• DOI: 10.1017/s1368980020002293
• 发表时间: 2021-06-01
• 期刊: PUBLIC HEALTH NUTRITION
• 影响因子: 3.2
• 作者: Mohammadi, Shooka;Su, Tin Tin;Majid, Hazreen Abdul
• 通讯作者: Majid, Hazreen Abdul

Malaysian Health and Adolescents Longitudinal Research Team (MyHeART) Study Handbook

马来西亚健康与青少年纵向研究小组（MyHeART）研究手册

• 发表时间: 2019
• 作者: Majid HA

School-Based Intervention to Improve Healthy Eating Practices Among Malaysian Adolescents: A Feasibility Study Protocol.

• DOI: 10.3389/fpubh.2020.549637
• 发表时间: 2020
• 期刊: Frontiers in public health
• 影响因子: 5.2
• 作者: Mohammadi S;Su TT;Jalaludin MY;Dahlui M;Azmi Mohamed MN;Papadaki A;Jago R;Toumpakari Z;Majid HA
• 通讯作者: Majid HA