The Epidemiology of Physical Activity and Lung Cancer

体力活动与肺癌的流行病学

• 批准号: 6888905
• 负责人: Andrew G Rundle
• 金额: $ 13.45万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-25 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6888905
• 关键词: adult human (21+); antioxidants; bioenergetics; biomarker; body physical activity; cancer risk; case history; clinical research; diet; exercise; glutathione; glutathione peroxidase; human subject; lifestyle; lung neoplasms; neoplasm /cancer epidemiology; nutrition aspect of cancer; oxidative stress; postdoctoral investigator; questionnaires; smoking; smoking cessation; tobacco abuse

DESCRIPTION (provided by applicant): This K award proposal encompasses training and research experiences designed to allow Dr. Rundle to develop into an independent researcher focusing on physical activity, and cancer epidemiology. The training component includes mentored work in physical activity and lifestyle risk factor epidemiology, lung cancer epidemiology, clinical aspects of lung cancer, and the use of biomarkers as intermediate endpoints. In addition, the plan includes biostatistics coursework, participation in seminar series and conferences, and trips to receive training at other institutions doing physical activity research. The proposed research includes a case-control study that will investigate whether physical activity, is protective against lung cancer, and a cross-sectional study that uses biomarkers as intermediate endpoints to investigate the mechanisms by which physical activity may act. The case-control study will follow up on cohort and case-control studies that have shown a protective effect of physical activity on lung cancer development and has the strength of more in depth life-time measures of physical activity and smoking habits. Furthermore, the study will be the first to control for diet as a potential confounder. Of particular interest is the affect of physical activity after smoking cessation and whether this has a protective effect. The biomarker study responds to calls for biomarker studies that can help to elucidate the protective mechanisms of physical activity. Such studies may provide biological support for observed associations with cancer, and will contribute information to determine the type, frequency, and duration of exercise needed for maximum protection. The study will determine whether physical activity is associated with increased levels of glutathione and extracellular glutathione peroxidase, and whether in turn these markers are associated with lower levels of PAH-DNA adducts and oxidative damage. Both projects are directed at the development of new lung cancer prevention programs that can supplement current smoking prevention and cessation programs.

描述（由申请人提供）：该 K 奖提案包括 旨在让 Rundle 博士发展成为 专注于身体活动和癌症的独立研究员 流行病学。培训内容包括体能方面的指导工作 活动和生活方式危险因素流行病学、肺癌流行病学、 肺癌的临床方面，以及生物标志物作为中间体的使用 端点。此外，该计划还包括生物统计学课程， 参加系列研讨会和会议以及接受培训的旅行 在其他机构从事体育活动研究。 拟议的研究包括一项病例对照研究，该研究将调查 体力活动是否能预防肺癌，以及横断面研究 使用生物标志物作为中间终点进行调查的研究 身体活动可能发挥作用的机制。病例对照研究 将跟进已显示保护性的队列和病例对照研究 体力活动对肺癌发展的影响，并具有以下作用： 对体力活动和吸烟习惯进行更深入的终生测量。 此外，该研究将是第一个将饮食控制作为潜在的研究 混淆者。特别令人感兴趣的是运动后体力活动的影响 戒烟以及这是否具有保护作用。生物标志物 这项研究响应了生物标志物研究的号召，这些研究可以帮助阐明 身体活动的保护机制。此类研究可能会提供 观察到的与癌症的关联的生物学支持，并将有助于 确定所需运动类型、频率和持续时间的信息 以获得最大程度的保护。该研究将确定身体活动是否 与谷胱甘肽和细胞外的水平增加有关 谷胱甘肽过氧化物酶，以及这些标记是否反过来与 较低水平的 PAH-DNA 加合物和氧化损伤。两个项目都是 旨在制定新的肺癌预防计划， 补充当前的吸烟预防和戒烟计划。