Immunomodulation and Vaccines

免疫调节和疫苗

• 批准号: MC_UU_00027/5
• 负责人: Alison Elliott
• 金额: $ 118.86万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00027%2F5
• 关键词: Immunomodulation; Vaccines

Human beings evolved in the presence of exposure to many infectious diseases, including viruses, bacteria and worms. Our immune systems evolved to protect us from these agents. However, some of them have develop strategies to evade or regulate the human immune response in such a way that they can live in their human hosts for decades, or for life. These include some parasites (worms, malaria) the bacteria that live in our gut and on our skin, and some viruses. In populations where infectious diseases have become uncommon it is likely that our immune systems develop differently compared to populations where infections are still common. This may have both benefits and disadvantages. We are investigating the hypothesis that exposure to infections, and especially chronic parasitic infections, alters 1. Responses to vaccines – generally in an adverse way, reducing desired, protective vaccine responses2. Responses to viruses which cause cancer – also reducing beneficial immune responses that control them3. Susceptibility to asthma and allergy4. Susceptibility to diabetesWe think that treating parasitic infections effectively may improve the response to vaccines and other infections, but increase the risk of allergy-related diseases and diabetes. Our studies are designed to find out whether this is so.

人类在暴露于许多传染病的情况下进化，包括病毒、细菌和蠕虫。我们的免疫系统进化来保护我们免受这些代理。然而，他们中的一些人已经制定了逃避或调节人类免疫反应的策略，使他们能够在人类宿主中生活数十年或终身。这些包括一些寄生虫（蠕虫，疟疾），生活在我们的肠道和皮肤上的细菌，以及一些病毒。在感染性疾病变得不常见的人群中，我们的免疫系统可能与感染仍然常见的人群不同。这可能既有好处也有坏处。我们正在调查的假设，暴露于感染，特别是慢性寄生虫感染，改变1。对疫苗的反应-通常是以不利的方式，减少所需的保护性疫苗反应2。对导致癌症的病毒的反应-也减少了控制它们的有益免疫反应3。易患哮喘和过敏4.对糖尿病的易感性我们认为，有效治疗寄生虫感染可能会改善对疫苗和其他感染的反应，但会增加过敏相关疾病和糖尿病的风险。我们的研究就是要弄清楚是否如此。

项目成果

Human postmortem studies reveal tissue-specific differences amongst TB-patient groups

• DOI: 10.1101/2023.03.14.532701
• 发表时间: 2023-03
• 期刊: bioRxiv
• 作者: Gift Ahimbisibwe;Marjorie Nakibuule;Marvin Martin Ssejoba;David Oyamo;Rose Mulwana;Josephine Nabulime;Febronius Babirye;Abdusalaamu Kizito;H. Lekuya;Akello Suzan Adakun;R. Lukande;A. Kyazze;I. A. Biraro;S. Cose

Establishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10-11, 2019.

• DOI: 10.1186/s13690-021-00650-z
• 发表时间: 2021-07-05
• 期刊: Archives of public health = Archives belges de sante publique
• 作者: Alabi A;Hussain M;Hoogerwerf MA;Mengome CN;Egesa M;Driciru E;Wammes LJ;Kruize YCM;Sartono E;Adegnika AA;Kremsner PG;Yazdanbakhsh M;Agnandji ST
• 通讯作者: Agnandji ST

Feasibility and acceptability of undertaking postmortem studies for tuberculosis medical research in a low income country.

• DOI: 10.3389/fimmu.2023.1264351
• 发表时间: 2023
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: Ahimbisibwe, Gift;Nakibuule, Marjorie;Martin Ssejoba, Marvin;Oyamo, David;Mulwana, Rose;Nabulime, Josephine;Babirye, Febronius;Kizito, Musana Abdusalaamu;Lekuya, Herve Monka;Adakun, Akello Suzan;Nalumansi, Daisy;Muryasingura, Stella;Lukande, Robert;Kyazze, Andrew;Baluku, Joseph Baruch;Biraro, Irene Andia;Cose, Stephen
• 通讯作者: Cose, Stephen

Anthelminthic treatment receipt and its predictors in Lake Victoria fishing communities, Uganda: Intervention coverage results from the LaVIISWA cluster randomised trial.

• DOI: 10.1371/journal.pntd.0008718
• 发表时间: 2020-10
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Akurut H;Sanya RE;Lubyayi L;Nampijja M;Kizza M;Kaweesa J;Kizindo R;Sewankambo M;Nsubuga D;Tukahebwa E;Kabatereine NB;Elliott AM;Webb EL;LaVIISWA trial team
• 通讯作者: LaVIISWA trial team

Clinical manifestations of Rift Valley fever in humans: Systematic review and meta-analysis.

• DOI: 10.1371/journal.pntd.0010233
• 发表时间: 2022-03
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Anywaine Z;Lule SA;Hansen C;Warimwe G;Elliott A
• 通讯作者: Elliott A