A transdiagnostic, translational approach to the understanding, prevention and treatment of mood, anxiety and stress disorders across the lifespan

一种跨诊断、转化的方法，用于理解、预防和治疗整个生命周期的情绪、焦虑和压力障碍

• 批准号: MC_UU_00030/5
• 负责人: Tim Dalgleish
• 金额: $ 353.08万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00030%2F5
• 关键词: transdiagnostic; translational; approach; understanding; prevention

Common mental health problems such as mood, anxiety and stress-related disorders are impact more than half of us during our lifetimes, and initially occur typically during childhood or adolescence. They are a leading worldwide cause of disability, health-service use, economic cost, and suffering. Even the best of our current treatments for these disorders leave around half of patients with ongoing disabling levels of distress, and problems commonly return later. Improving the treatment and prevention of these conditions is therefore a priority. This programme uses what we call ‘basic science’ to further understand the nature of these disorders using different methods from brain imaging through to psychological experiments. We then use these basic findings to develop and improve our psychological treatments for these disorders, for children adolescents and adults. These treatments are then evaluated within what we call randomised controlled trials, where the new/improved treatment is compared against an existing treatment which we already know works, to see if the new treatment is as good or better.

常见的心理健康问题，如情绪、焦虑和与压力有关的疾病，在我们的一生中影响着一半以上的人，最初通常发生在童年或青春期。它们是世界范围内造成残疾、卫生服务使用、经济成本和痛苦的主要原因。即使是我们目前对这些疾病最好的治疗方法，也会让大约一半的患者持续处于致残的痛苦水平，而且问题通常会在之后再次出现。因此，改善这些疾病的治疗和预防是一个优先事项。本节目使用我们所谓的“基础科学”，通过从脑成像到心理实验的不同方法来进一步了解这些疾病的本质。然后，我们利用这些基本发现来发展和改进针对儿童、青少年和成人的心理治疗方法。然后在我们所谓的随机对照试验中对这些治疗方法进行评估，将新的/改进的治疗方法与我们已知有效的现有治疗方法进行比较，看看新治疗方法是否同样好或更好。

项目成果

Protocol for a randomised controlled trial investigating an intervention to boost decentering in response to distressing mental experiences during adolescence: the decentering in adolescence study (DECADES).

• DOI: 10.1136/bmjopen-2021-056864
• 发表时间: 2022-03-30
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Bennett MP;Knight RC;Dunning D;Archer-Boyd A;Blakemore SJ;Dalmaijer E;Ford T;Williams JMG;Clegg H;Kuyken W;So T;Wright G;Lenaert B;Vainre M;Watson P;MYRIAD Team;Dalgleish T
• 通讯作者: Dalgleish T

Efficacy and moderators of efficacy of cognitive behavioural therapies with a trauma focus in children and adolescents: an individual participant data meta-analysis of randomised trials.

• DOI: 10.1016/s2352-4642(23)00253-5
• 发表时间: 2023-11
• 期刊: The Lancet. Child & adolescent health
• 作者: Anke de Haan;R. Meiser-Stedman;Markus A. Landolt;Isla Kuhn;Melissa J Black;Kristel Klaus;Shivam D. Patel;David J Fisher;C. Haag;O. Ukoumunne;Benjamin G Jones;Ashraf Muwafaq Flaiyah;Claudia Catani;K. Dawson;Richard A. Bryant;C. de Roos;Verena Ertl;Edna B. Foa;Julian D Ford;E. Gilboa-Schechtman;D. Tutus;Katharin Hermenau;Tobias Hecker;Ole Hultmann;Ulf Axberg;Nasrin Jaberghaderi;T. Jensen;S. Ormhaug;J. Kenardy;Ramon Lindauer;Julia Diehle;Laura K. Murray;J. Kane;Kirsi Peltonen;Samuli Kangaslampi;K. Robjant;Anke Koebach;R. Rosner;J. Rossouw;Patrick Smith;Bruce J Tonge;C. Hitchcock;T. Dalgleish

A core component of psychological therapy causes adaptive changes in computational learning mechanisms.

心理治疗的核心组成部分会引起计算学习机制的适应性变化。

• DOI: 10.1017/s0033291723001587
• 发表时间: 2023
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Dercon Q

The development and internal evaluation of a predictive model to identify for whom Mindfulness-Based Cognitive Therapy (MBCT) offers superior relapse prevention for recurrent depression versus maintenance antidepressant medication.

• DOI: 10.1177/21677026221076832
• 发表时间: 2023-01
• 期刊: Clinical psychological science : a journal of the Association for Psychological Science
• 作者: Cohen ZD;DeRubeis RJ;Hayes R;Watkins ER;Lewis G;Byng R;Byford S;Crane C;Kuyken W;Dalgleish T;Schweizer S
• 通讯作者: Schweizer S

Reappraisal capacity is unrelated to depressive and anxiety symptoms.

• DOI: 10.1038/s41598-023-33917-2
• 发表时间: 2023-05-03
• 期刊: Scientific reports
• 影响因子: 4.6