Systems neuroscience of human long-term memory, ageing and dementia

人类长期记忆、衰老和痴呆的系统神经科学

• 批准号: MC_UU_00030/8
• 负责人: Richard Henson
• 金额: $ 313.96万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00030%2F8
• 关键词: Systems; neuroscience; human; long; term

We are trying to understand how our brains support different types of memory, which is important to understand the type of memory problems that follow brain damage or disease, or following normal ageing. Our memories express themselves in different ways. For example, sometimes you see a face in a crowd and immediately remember who it is, and when you last saw them. On other occasions, the face might seem familiar, but you can't for the life of you remember who they are. These are two expressions of conscious memory. On yet other occasions, you may insist you have no memory for the person, even though other aspects of your behaviour, such as your attitude towards them, can be shown to be biased by the fact that you have, in fact, seen them before. This is a type of unconscious memory. Recent research suggests that these different expressions of memory reflect the operation of distinct neural systems in our brains. The aim of our research is to explore the differences between these types of memory, and their neural bases, using functional neuroimaging techniques that measure brain activity while people are remembering things. Understanding conscious and unconscious memory is important not only for helping people who suffer from memory problems following brain damage, such as strokes, or following disease, such as Alzheimer's, but for all of us who experience memory problems as we grow older.

我们试图了解我们的大脑如何支持不同类型的记忆，这对于了解大脑损伤或疾病或正常衰老后的记忆问题类型很重要。我们的记忆以不同的方式表达自己。例如，有时候你在人群中看到一张脸，立刻就能想起那是谁，以及你最后一次见到他们是什么时候。在其他情况下，这张脸可能看起来很熟悉，但你却无法记住他们是谁。这是有意识记忆的两种表现形式。在其他情况下，你可能会坚持说你对这个人没有记忆，即使你行为的其他方面，比如你对他们的态度，可以被证明是有偏见的，因为你以前见过他们。这是一种无意识的记忆。最近的研究表明，这些不同的记忆表达反映了我们大脑中不同神经系统的运作。我们研究的目的是探索这些类型的记忆之间的差异，以及它们的神经基础，使用功能性神经成像技术来测量人们记忆事物时的大脑活动。了解有意识和无意识记忆不仅对帮助那些在脑损伤（如中风）或阿尔茨海默氏症等疾病后出现记忆问题的人很重要，而且对我们所有随着年龄增长而出现记忆问题的人也很重要。

项目成果

Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.

• DOI: 10.1093/cercor/bhab290
• 发表时间: 2022-04-05
• 期刊: Cerebral cortex (New York, N.Y. : 1991)

Inconsistent generalisation of structured knowledge between 2-dimensional conceptual spaces

二维概念空间之间结构化知识的概括不一致

• DOI: 10.31234/osf.io/kpaz5
• 发表时间: 2022
• 作者: Bokeria L

Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment

健康老年人和有轻度认知障碍风险的人的内侧颞叶结构、记忆和知觉辨别

• DOI: 10.1101/2022.05.13.491810
• 发表时间: 2022
• 作者: Gellersen H

Distinct roles for the anterior temporal lobe and angular gyrus in the spatiotemporal cortical semantic network.

• DOI: 10.1093/cercor/bhab501
• 发表时间: 2022-10-08
• 期刊: Cerebral cortex (New York, N.Y. : 1991)

Stakeholder engagement in European brain research: Experiences of the Lifebrain consortium.

利益相关者参与欧洲大脑研究：Lifebrain 联盟的经验。

• DOI: 10.17863/cam.95517
• 发表时间: 2023
• 作者: Budin-Ljøsne I